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Tclin
TUBB4A
Tubulin beta-4A chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264071
  • ENSP00000264071
  • ENSG00000104833

Symbol
  • TUBB4
  • TUBB5
  • DYT4
  • TUBB4
  • beta-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.97
protein domain
0.97
molecular function
0.94
gene perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2082.59   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2082.59   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
paclitaxel
Rendered image for paclitaxel
docetaxel
Rendered image for docetaxel
brentuximab vedotin
no chemical structure image available
vinblastine
Rendered image for vinblastine
vinorelbine
Rendered image for vinorelbine
trastuzumab emtansine
no chemical structure image available
polatuzumab vedotin
no chemical structure image available
enfortumab vedotin
no chemical structure image available
ixabepilone
Rendered image for ixabepilone
vincristine
Rendered image for vincristine
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
CAPS
Tbio
Novelty:  0.04549022
p_int:  0.994474562
p_ni:  0.005525438
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.990868899
p_ni:  0.009131101
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.954402333
p_ni:  0.045597667
Score:  0.151
Data Source:  BioPlex,STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.93130416
p_ni:  0.06869584
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.925355401
p_ni:  0.074644598
Data Source:  BioPlex
TPSB2
Tchem
Family:  Enzyme
Novelty:  0.00757397
p_int:  0.922143571
p_ni:  0.077856429
Data Source:  BioPlex
FAS
Tbio
Novelty:  0.00043286
p_int:  0.914062523
p_ni:  0.085937477
Score:  0.152
Data Source:  BioPlex,STRINGDB
TUBB
Tclin
Novelty:  0.0038007
p_int:  0.907822726
p_ni:  0.092177274
Score:  0.92
Data Source:  BioPlex,STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.872287074
p_ni:  0.127712926
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.87036905
p_ni:  0.12963095
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Carboxyterminal post-translational modifications of tubulin
Cell Cycle
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
5.9
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107848
22153
Rat
RGD:619730
29213
Dog
tubulin beta 4A class IVa
VGNC:47989
100855815
Cow
tubulin beta 4A class IVa
VGNC:36507
540236
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tubulin beta 4A class IVa
Cow
tubulin beta 4A class IVa
Publication Statistics
PubMed Score 2082.59
PubMed score by year
PubTator Score 86.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title