Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]
- ENST00000264071
- ENSP00000264071
- ENSG00000104833
- TUBB4
- TUBB5
- DYT4
- TUBB4
- beta-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.99 | ||
interacting protein | 0.97 | ||
protein domain | 0.97 | ||
molecular function | 0.94 | ||
gene perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2082.59 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2082.59 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
Active Ligands (0)
Protein-Protein Interactions (279)
LRP1
Novelty: 0.00200788
p_int: 0.954402333
p_ni: 0.045597667
Score: 0.151
Data Source: BioPlex,STRINGDB
TPSB2
Family: Enzyme
Novelty: 0.00757397
p_int: 0.922143571
p_ni: 0.077856429
Data Source: BioPlex
FAS
Novelty: 0.00043286
p_int: 0.914062523
p_ni: 0.085937477
Score: 0.152
Data Source: BioPlex,STRINGDB
TUBB
Novelty: 0.0038007
p_int: 0.907822726
p_ni: 0.092177274
Score: 0.92
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (25)
KEGG (3)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Carboxyterminal post-translational modifications of tubulin | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (4)
Components (9)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1 | 5.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1 | 5.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:107848 | 22153 | ||||||
Rat | RGD:619730 | 29213 | ||||||
Dog | tubulin beta 4A class IVa | VGNC:47989 | 100855815 | |||||
Cow | tubulin beta 4A class IVa | VGNC:36507 | 540236 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | tubulin beta 4A class IVa | |||||
Cow | tubulin beta 4A class IVa | |||||
Publication Statistics
PubMed Score 2082.59
PubMed score by year
PubTator Score 86.76
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
|---|