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Tclin
TUBB2B
Tubulin beta-2B chain

Protein Summary
Description
Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259818
  • ENSP00000259818
  • ENSG00000137285

Symbol
  • CDCBM7
  • PMGYSA
  • bA506K6.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
protein domain
0.97
molecular function
0.94
PubMedID
0.9
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
paclitaxel
Rendered image for paclitaxel
docetaxel
Rendered image for docetaxel
brentuximab vedotin
no chemical structure image available
vinblastine
Rendered image for vinblastine
vinorelbine
Rendered image for vinorelbine
trastuzumab emtansine
no chemical structure image available
polatuzumab vedotin
no chemical structure image available
enfortumab vedotin
no chemical structure image available
ixabepilone
Rendered image for ixabepilone
vincristine
Rendered image for vincristine
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999999703
p_ni:  2.96e-7
Score:  0.934
Data Source:  BioPlex,STRINGDB
EML2
Tbio
Novelty:  0.09538181
p_int:  0.99999965
p_ni:  3.49e-7
p_wrong:  1e-9
Score:  0.697
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999968719
p_ni:  0.000031281
Score:  0.909
Data Source:  BioPlex,STRINGDB
EML1
Tbio
Novelty:  0.02262549
p_int:  0.999949733
p_ni:  0.000050267
Score:  0.704
Data Source:  BioPlex,STRINGDB
TBCD
Tbio
Novelty:  0.01161221
p_int:  0.999834458
p_ni:  0.000165542
Score:  0.961
Data Source:  BioPlex,STRINGDB
EML6
Tdark
Novelty:  0.40631576
p_int:  0.999058346
p_ni:  6.02e-7
p_wrong:  0.000941052
Score:  0.812
Data Source:  BioPlex,STRINGDB
TTC5
Tbio
Novelty:  0.12127698
p_int:  0.996096882
p_ni:  0.003903118
Score:  0.607
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.97997305
p_ni:  0.02002695
Score:  0.199
Data Source:  BioPlex,STRINGDB
TCP11L1
Tdark
Novelty:  1.5011461
p_int:  0.977677458
p_ni:  0.022322542
Score:  0.831
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.974433994
p_ni:  0.025566004
p_wrong:  1e-9
Score:  0.91
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
71.6
electrocardiography
1
1
33
56.4
mean platelet volume
1
1
1
45.2
mean reticulocyte volume
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
71.6
electrocardiography
33
56.4
mean platelet volume
1
45.2
mean reticulocyte volume
1
4.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920960
73710
Rat
RGD:1309427
291081
Dog
tubulin beta 2B class IIb
478702
Cow
tubulin, beta 2B class IIb
281555
Xenopus
tubulin beta 2B class IIb
XB-GENE-491121
394889
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tubulin beta 2B class IIb
Cow
tubulin, beta 2B class IIb
Xenopus
tubulin beta 2B class IIb
Publication Statistics
PubMed Score 32.28
PubMed score by year
PubTator Score 21.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title