Protein Summary
Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
- ENST00000259818
- ENSP00000259818
- ENSG00000137285
- CDCBM7
- PMGYSA
- bA506K6.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.98 | ||
protein domain | 0.97 | ||
molecular function | 0.94 | ||
PubMedID | 0.9 | ||
hub protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.28 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 314 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.28 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 314 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
Active Ligands (0)
Protein-Protein Interactions (127)
ARL2
Family: Enzyme
Novelty: 0.01989908
p_int: 0.999999703
p_ni: 2.96e-7
Score: 0.934
Data Source: BioPlex,STRINGDB
EML2
Novelty: 0.09538181
p_int: 0.99999965
p_ni: 3.49e-7
p_wrong: 1e-9
Score: 0.697
Data Source: BioPlex,STRINGDB
TUBB1
Novelty: 0.02806117
p_int: 0.999968719
p_ni: 0.000031281
Score: 0.909
Data Source: BioPlex,STRINGDB
EML1
Novelty: 0.02262549
p_int: 0.999949733
p_ni: 0.000050267
Score: 0.704
Data Source: BioPlex,STRINGDB
TBCD
Novelty: 0.01161221
p_int: 0.999834458
p_ni: 0.000165542
Score: 0.961
Data Source: BioPlex,STRINGDB
EML6
Novelty: 0.40631576
p_int: 0.999058346
p_ni: 6.02e-7
p_wrong: 0.000941052
Score: 0.812
Data Source: BioPlex,STRINGDB
TTC5
Novelty: 0.12127698
p_int: 0.996096882
p_ni: 0.003903118
Score: 0.607
Data Source: BioPlex,STRINGDB
EPHA4
Family: Kinase
Novelty: 0.00321698
p_int: 0.97997305
p_ni: 0.02002695
Score: 0.199
Data Source: BioPlex,STRINGDB
TCP11L1
Novelty: 1.5011461
p_int: 0.977677458
p_ni: 0.022322542
Score: 0.831
Data Source: BioPlex,STRINGDB
TUBB8
Novelty: 0.06403117
p_int: 0.974433994
p_ni: 0.025566004
p_wrong: 1e-9
Score: 0.91
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (9)
KEGG (3)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Carboxyterminal post-translational modifications of tubulin | ||||
Reactome | Chaperonin-mediated protein folding | ||||
Reactome | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Reactome | Formation of tubulin folding intermediates by CCT/TriC | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Carboxyterminal post-translational modifications of tubulin | ||||
Chaperonin-mediated protein folding | ||||
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||||
Formation of tubulin folding intermediates by CCT/TriC | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 2 | 3 | 71.6 | |||||
electrocardiography | 1 | 1 | 33 | 56.4 | |||||
mean platelet volume | 1 | 1 | 1 | 45.2 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 4.7 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 71.6 | |||||
electrocardiography | 33 | 56.4 | |||||
mean platelet volume | 1 | 45.2 | |||||
mean reticulocyte volume | 1 | 4.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1920960 | 73710 | ||||||
Rat | RGD:1309427 | 291081 | ||||||
Dog | tubulin beta 2B class IIb | 478702 | ||||||
Cow | tubulin, beta 2B class IIb | 281555 | ||||||
Xenopus | tubulin beta 2B class IIb | XB-GENE-491121 | 394889 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | tubulin beta 2B class IIb | |||||
Cow | tubulin, beta 2B class IIb | |||||
Xenopus | tubulin beta 2B class IIb | |||||
Publication Statistics
PubMed Score 32.28
PubMed score by year
PubTator Score 21.06
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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