Tclin TUBB2B Tubulin beta-2B chain

Protein Summary

Description

Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9BVA1
• A8K068

Gene Name

• TUBB2B

Ensembl ID

• ENST00000259818
• ENSP00000259818
• ENSG00000137285

Symbol

• CDCBM7
• PMGYSA
• bA506K6.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
protein domain	0.97
molecular function	0.94
PubMedID	0.9
hub protein	0.85

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-2b Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta-2b Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (13)

Explore Approved Drugs

1 – 10 of 13

paclitaxel

TUBB2BTclin

INHIBITOR pEC50 : 8.05

docetaxel

TUBB2BTclin

INHIBITOR pID50 : 6.7

brentuximab vedotin

TUBB2BTclin

INHIBITOR :

vinblastine

TUBB2BTclin

INHIBITOR pIC50 : 9

vinorelbine

TUBB2BTclin

INHIBITOR :

trastuzumab emtansine

TUBB2BTclin

ANTIBODY BINDING :

polatuzumab vedotin

TUBB2BTclin

BINDING AGENT :

enfortumab vedotin

TUBB2BTclin

BINDING AGENT pKi : 10.24

ixabepilone

TUBB2BTclin

INHIBITOR :

vincristine

TUBB2BTclin

INHIBITOR :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (127)

Explore Interacting Targets

1 – 10 of 127

• See Interactions on String-DB

ARL2

Tbio

Family:  Enzyme

Novelty:  0.01989908

p_int:  0.999999703

p_ni:  2.96e-7

Score:  0.934

Data Source:  BioPlex,STRINGDB

EML2

Tbio

Novelty:  0.09538181

p_int:  0.99999965

p_ni:  3.49e-7

p_wrong:  1e-9

Score:  0.697

Data Source:  BioPlex,STRINGDB

TUBB1

Tclin

Novelty:  0.02806117

p_int:  0.999968719

p_ni:  0.000031281

Score:  0.909

Data Source:  BioPlex,STRINGDB

EML1

Tbio

Novelty:  0.02262549

p_int:  0.999949733

p_ni:  0.000050267

Score:  0.704

Data Source:  BioPlex,STRINGDB

TBCD

Tbio

Novelty:  0.01161221

p_int:  0.999834458

p_ni:  0.000165542

Score:  0.961

Data Source:  BioPlex,STRINGDB

EML6

Tdark

Novelty:  0.40631576

p_int:  0.999058346

p_ni:  6.02e-7

p_wrong:  0.000941052

Score:  0.812

Data Source:  BioPlex,STRINGDB

TTC5

Tbio

Novelty:  0.12127698

p_int:  0.996096882

p_ni:  0.003903118

Score:  0.607

Data Source:  BioPlex,STRINGDB

EPHA4

Tchem

Family:  Kinase

Novelty:  0.00321698

p_int:  0.97997305

p_ni:  0.02002695

Score:  0.199

Data Source:  BioPlex,STRINGDB

TCP11L1

Tdark

Novelty:  1.5011461

p_int:  0.977677458

p_ni:  0.022322542

Score:  0.831

Data Source:  BioPlex,STRINGDB

TUBB8

Tclin

Novelty:  0.06403117

p_int:  0.974433994

p_ni:  0.025566004

p_wrong:  1e-9

Score:  0.91

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (9)

KEGG (3)

PathwayCommons (2)

WikiPathways (2)

Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

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Find Similar Targets

Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Reactome	Formation of tubulin folding intermediates by CCT/TriC	26 targets	R-HSA-389960
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Carboxyterminal post-translational modifications of tubulin	38 targets	R-HSA-8955332
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Formation of tubulin folding intermediates by CCT/TriC	26 targets	R-HSA-389960
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (5)

Processes (6)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	3	2	3		71.6
electrocardiography	EFO_0004327	1	1	33		56.4
mean platelet volume	EFO_0004584	1	1	1		45.2
mean reticulocyte volume	EFO_0010701	1	1	1		4.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	3		71.6
electrocardiography	EFO_0004327	33		56.4
mean platelet volume	EFO_0004584	1		45.2
mean reticulocyte volume	EFO_0010701	1		4.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Mental retardation

GWAS Trait Find Similar Targets

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electrocardiography
mean platelet volume
mean reticulocyte volume
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	tubulin, beta 2B class IIB	MGI:1920960	73710
Rat	tubulin, beta 2B class IIb	RGD:1309427	291081
Dog	tubulin beta 2B class IIb		478702
Cow	tubulin, beta 2B class IIb		281555
Xenopus	tubulin beta 2B class IIb	XB-GENE-491121	394889

Species	Name	OMA	EggNOG	Inparanoid
Mouse	tubulin, beta 2B class IIB
Rat	tubulin, beta 2B class IIb
Dog	tubulin beta 2B class IIb
Cow	tubulin, beta 2B class IIb
Xenopus	tubulin beta 2B class IIb

Publication Statistics

PubMed Score 32.28

PubMed score by year

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PubTator Score 21.06

PubTator score by year

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Related Publications

Text Mined References (27)

GeneRif Annotations (16)

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10

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PMID	Year	Title