Tclin TUBB Tubulin beta chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• P07437
• P05218
• Q8WUC1
• Q9CY33

Gene Name

• TUBB

Ensembl ID

• ENST00000327892
• ENSP00000339001
• ENSG00000196230
• ENST00000383564
• ENSP00000373058
• ENSG00000183311
• ENST00000419792
• ENSP00000401317
• ENSG00000235067
• ENST00000421473
• ENSP00000399155
• ENSG00000224156
• ENST00000422650
• ENSP00000400663
• ENSG00000229684
• ENST00000422674
• ENSP00000406811
• ENSG00000227739
• ENST00000432462
• ENSP00000410829
• ENSG00000232421
• ENST00000436628
• ENSP00000410071
• ENSG00000232575

Symbol

• TUBB5
• M40
• TUBB1
• TUBB5
• CDCBM6
• CSCSC1
• OK/SW-cl.56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
kinase perturbation	0.99
molecular function	0.99
transcription factor perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.38   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 921   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.38   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 921   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (13)

Explore Approved Drugs

1 – 10 of 13

paclitaxel

TUBBTclin

INHIBITOR pEC50 : 8.05

docetaxel

TUBBTclin

INHIBITOR pID50 : 6.7

brentuximab vedotin

TUBBTclin

INHIBITOR :

vinblastine

TUBBTclin

INHIBITOR pIC50 : 9

vinorelbine

TUBBTclin

INHIBITOR :

trastuzumab emtansine

TUBBTclin

ANTIBODY BINDING :

polatuzumab vedotin

TUBBTclin

BINDING AGENT :

enfortumab vedotin

TUBBTclin

BINDING AGENT pKi : 10.24

ixabepilone

TUBBTclin

INHIBITOR :

vincristine

TUBBTclin

INHIBITOR :

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

colchicine

TUBBTclin

pKi : 6.92

Protein-Protein Interactions (368)

Explore Interacting Targets

1 – 10 of 368

• See Interactions on String-DB

ARL2

Tbio

Family:  Enzyme

Novelty:  0.01989908

p_int:  0.999998154

p_ni:  0.000001846

Score:  0.621

Data Source:  BioPlex,STRINGDB

TBCD

Tbio

Novelty:  0.01161221

p_int:  0.999939842

p_ni:  0.000060158

Score:  0.811

Data Source:  BioPlex,STRINGDB

TTC5

Tbio

Novelty:  0.12127698

p_int:  0.999777163

p_ni:  0.000222837

Score:  0.554

Data Source:  BioPlex,STRINGDB

TUBB3

Tclin

Novelty:  0.00195963

p_int:  0.995895241

p_ni:  0.004104759

Score:  0.2

Data Source:  BioPlex,STRINGDB

PLD2

Tchem

Family:  Enzyme

Novelty:  0.00331129

p_int:  0.995361263

p_ni:  0.004638737

Data Source:  BioPlex

TCP11L1

Tdark

Novelty:  1.5011461

p_int:  0.992960857

p_ni:  0.007039143

Score:  0.839

Data Source:  BioPlex,STRINGDB

EPHA4

Tchem

Family:  Kinase

Novelty:  0.00321698

p_int:  0.98695319

p_ni:  0.01304681

Score:  0.158

Data Source:  BioPlex,STRINGDB

EML1

Tbio

Novelty:  0.02262549

p_int:  0.986882784

p_ni:  0.013117216

Score:  0.827

Data Source:  BioPlex,STRINGDB

ZNHIT6

Tbio

Novelty:  1.1021845

p_int:  0.983915895

p_ni:  0.016084094

p_wrong:  1.2e-8

Data Source:  BioPlex

TUBB8

Tclin

Novelty:  0.06403117

p_int:  0.981458425

p_ni:  0.01854157

p_wrong:  5e-9

Score:  0.397

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (89)

Reactome (19)

KEGG (3)

PathwayCommons (3)

WikiPathways (64)

AURKA Activation by TPX2 (R-HSA-8854518)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (9)

Components (11)

Processes (13)

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10

1 – 9 of 9

GO Term	Evidence	Assigned by
MHC class I protein binding	Inferred from Direct Assay (IDA)	UniProtKB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural molecule activity	Traceable Author Statement (TAS)	BHF-UCL
GTPase activating protein binding	Inferred from Electronic Annotation (IEA)	Ensembl
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (162)

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5

1 – 5 of 162

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronic obstructive pulmonary disease	EFO_0000341	ENSG00000196230	2	2	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	ENSG00000232575	2	2	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	ENSG00000183311	2	2	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	ENSG00000232421	2	2	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	ENSG00000227739	2	2	0	1.1	85.8

Items per page:

5

1 – 5 of 162

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	85.8
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	85.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
age-related macular degeneration
alcohol dependence measurement
autism spectrum disorder
autoimmune thyroid disease
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
cervical carcinoma
chronic obstructive pulmonary disease
colorectal cancer

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	tubulin beta class I		574113
Mouse	tubulin, beta 5 class I	MGI:107812	22154
Rat	tubulin, beta 5 class I	RGD:628596	29214
Dog	tubulin beta class I		474830
Horse	tubulin beta class I	VGNC:49368	100051013

Species	Name	OMA	EggNOG	Inparanoid
Macaque	tubulin beta class I
Mouse	tubulin, beta 5 class I
Rat	tubulin, beta 5 class I
Dog	tubulin beta class I
Horse	tubulin beta class I

Publication Statistics

PubMed Score 233.38

PubMed score by year

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PubTator Score 60.80

PubTator score by year

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Related Publications

Text Mined References (79)

GeneRif Annotations (33)

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PMID	Year	Title