TUBB
Tubulin beta chain
Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
- ENST00000327892
- ENSP00000339001
- ENSG00000196230
- ENST00000383564
- ENSP00000373058
- ENSG00000183311
- ENST00000419792
- ENSP00000401317
- ENSG00000235067
- ENST00000421473
- ENSP00000399155
- ENSG00000224156
- ENST00000422650
- ENSP00000400663
- ENSG00000229684
- ENST00000422674
- ENSP00000406811
- ENSG00000227739
- ENST00000432462
- ENSP00000410829
- ENSG00000232421
- ENST00000436628
- ENSP00000410071
- ENSG00000232575
- TUBB5
- M40
- TUBB1
- TUBB5
- CDCBM6
- CSCSC1
- OK/SW-cl.56
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 0.99 | ||
molecular function | 0.99 | ||
transcription factor perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 290.91 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 921 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 290.91 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 921 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 14