Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
- ENST00000327892
- ENSP00000339001
- ENSG00000196230
- ENST00000383564
- ENSP00000373058
- ENSG00000183311
- ENST00000419792
- ENSP00000401317
- ENSG00000235067
- ENST00000421473
- ENSP00000399155
- ENSG00000224156
- ENST00000422650
- ENSP00000400663
- ENSG00000229684
- ENST00000422674
- ENSP00000406811
- ENSG00000227739
- ENST00000432462
- ENSP00000410829
- ENSG00000232421
- ENST00000436628
- ENSP00000410071
- ENSG00000232575
- TUBB5
- M40
- TUBB1
- TUBB5
- CDCBM6
- CSCSC1
- OK/SW-cl.56
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 0.99 | ||
molecular function | 0.99 | ||
transcription factor perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 233.38 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 921 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 233.38 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 921 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
Active Ligands (1)
Protein-Protein Interactions (368)
ARL2
Family: Enzyme
Novelty: 0.01989908
p_int: 0.999998154
p_ni: 0.000001846
Score: 0.621
Data Source: BioPlex,STRINGDB
TBCD
Novelty: 0.01161221
p_int: 0.999939842
p_ni: 0.000060158
Score: 0.811
Data Source: BioPlex,STRINGDB
TTC5
Novelty: 0.12127698
p_int: 0.999777163
p_ni: 0.000222837
Score: 0.554
Data Source: BioPlex,STRINGDB
TUBB3
Novelty: 0.00195963
p_int: 0.995895241
p_ni: 0.004104759
Score: 0.2
Data Source: BioPlex,STRINGDB
PLD2
Family: Enzyme
Novelty: 0.00331129
p_int: 0.995361263
p_ni: 0.004638737
Data Source: BioPlex
TCP11L1
Novelty: 1.5011461
p_int: 0.992960857
p_ni: 0.007039143
Score: 0.839
Data Source: BioPlex,STRINGDB
EPHA4
Family: Kinase
Novelty: 0.00321698
p_int: 0.98695319
p_ni: 0.01304681
Score: 0.158
Data Source: BioPlex,STRINGDB
EML1
Novelty: 0.02262549
p_int: 0.986882784
p_ni: 0.013117216
Score: 0.827
Data Source: BioPlex,STRINGDB
ZNHIT6
Novelty: 1.1021845
p_int: 0.983915895
p_ni: 0.016084094
p_wrong: 1.2e-8
Data Source: BioPlex
TUBB8
Novelty: 0.06403117
p_int: 0.981458425
p_ni: 0.01854157
p_wrong: 5e-9
Score: 0.397
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (89)
Reactome (19)
KEGG (3)
PathwayCommons (3)
WikiPathways (64)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Centrosome maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Centrosome maturation | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (9)
Components (11)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (162)
Items per page:
1 – 5 of 162
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
Items per page:
1 – 5 of 162
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | tubulin beta class I | 574113 | ||||||
Mouse | MGI:107812 | 22154 | ||||||
Rat | RGD:628596 | 29214 | ||||||
Dog | tubulin beta class I | 474830 | ||||||
Horse | tubulin beta class I | VGNC:49368 | 100051013 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | tubulin beta class I | |||||
Mouse | ||||||
Rat | ||||||
Dog | tubulin beta class I | |||||
Horse | tubulin beta class I | |||||
Publication Statistics
PubMed Score 233.38
PubMed score by year
PubTator Score 60.80
PubTator score by year
Related Publications
Text Mined References (79)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
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