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Tchem
TUBA1B
Tubulin alpha-1B chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336023
  • ENSP00000336799
  • ENSG00000123416

Symbol
  • K-ALPHA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
molecular function
0.98
virus perturbation
0.98
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.41   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 575   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.41   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 575   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (180)
TCP11L2
Tdark
Novelty:  1.78903335
p_int:  0.999999611
p_ni:  3.89e-7
Score:  0.753
Data Source:  BioPlex,STRINGDB
TXNDC9
Tbio
Novelty:  0.00309772
p_int:  0.99979614
p_ni:  0.00020386
Score:  0.852
Data Source:  BioPlex,STRINGDB
DLGAP5
Tbio
Novelty:  0.01673312
p_int:  0.996772343
p_ni:  0.00322749
p_wrong:  1.67e-7
Score:  0.249
Data Source:  BioPlex,STRINGDB
TUBA1C
Tchem
Novelty:  0.02804632
p_int:  0.996115761
p_ni:  0.003884239
Score:  0.995
Data Source:  BioPlex,STRINGDB
TUBA1A
Tchem
Novelty:  0.01030145
p_int:  0.959904154
p_ni:  0.040095846
Score:  0.999
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.952596946
p_ni:  0.047403054
Data Source:  BioPlex
CST8
Tbio
Novelty:  0.02316886
p_int:  0.938245648
p_ni:  0.061754352
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.927905917
p_ni:  0.072094083
Score:  0.96
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.91465665
p_ni:  0.08534335
Score:  0.916
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.878881818
p_ni:  0.121118182
Score:  0.954
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
1 – 5 of 9
TUBB
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB4A
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
TUBB4B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  3
Pathways (53)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
3
1
6.6
73
cognitive function measurement
1
1
1
66.3
HbA1c measurement
1
1
1
57.8
mean corpuscular hemoglobin concentration
1
1
1
51.7
2
2
1
1.1
38.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.6
73
cognitive function measurement
1
66.3
HbA1c measurement
1
57.8
mean corpuscular hemoglobin concentration
1
51.7
1
1.1
38.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107804
22143
Rat
RGD:1565476
500929
Cow
tubulin, alpha 1b
539882
Pig
Tubulin alpha-1B chain Detyrosinated tubulin alpha-1B chain [Source:UniProtKB/Swiss-Prot;Acc:Q2XVP4]
Opossum
tubulin alpha 1b
100010347
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
tubulin, alpha 1b
Pig
Tubulin alpha-1B chain Detyrosinated tubulin alpha-1B chain [Source:UniProtKB/Swiss-Prot;Acc:Q2XVP4]
Opossum
tubulin alpha 1b
Publication Statistics
PubMed Score 36.41
PubMed score by year
PubTator Score 317.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title