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Tbio
TTYH3
Protein tweety homolog 3

Protein Summary
Description
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258796
  • ENSP00000258796
  • ENSG00000136295
  • ENST00000403167
  • ENSP00000385015
  • ENST00000407643
  • ENSP00000385316

Symbol
  • KIAA1691
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.8
transcription factor perturbation
0.74
transcription factor binding site profile
0.7
molecular function
0.63
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.997657809
p_ni:  0.002342191
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.996884432
p_ni:  0.003115568
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.994172148
p_ni:  0.005827851
Data Source:  BioPlex
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.974605521
p_ni:  0.024524062
p_wrong:  0.000870417
Data Source:  BioPlex
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
p_int:  0.960641163
p_ni:  0.039358837
Data Source:  BioPlex
CDKAL1
Tbio
Family:  Enzyme
Novelty:  0.01013607
p_int:  0.96030617
p_ni:  0.039693829
p_wrong:  2e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.958694772
p_ni:  0.041305227
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.9280505
p_ni:  0.071948888
p_wrong:  6.12e-7
Data Source:  BioPlex
CD27
Tbio
Novelty:  0.00090508
p_int:  0.925277923
p_ni:  0.074722077
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.921813837
p_ni:  0.078186163
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
5
7
5.9
98.3
BMI-adjusted hip circumference
3
19
24
97.6
body fat distribution
2
1
5
83.1
birth weight
5
5
5
77
anthropometric measurement
1
1
0
1.2
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
5.9
98.3
BMI-adjusted hip circumference
24
97.6
body fat distribution
5
83.1
birth weight
5
77
anthropometric measurement
0
1.2
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tweety family member 3
VGNC:4553
738594
Macaque
tweety family member 3
714138
Mouse
MGI:1925589
78339
Rat
RGD:1309549
304315
Dog
tweety family member 3
VGNC:47985
489890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tweety family member 3
Macaque
tweety family member 3
Mouse
Rat
Dog
tweety family member 3
Publication Statistics
PubMed Score 5.61
PubMed score by year
PubTator Score 2.20
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title