TTYH1
Protein tweety homolog 1
Protein Summary
Probable chloride channel. May be involved in cell adhesion (By similarity). Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume. This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011]
- ENST00000301194
- ENSP00000301194
- ENSG00000167614
- ENST00000376530
- ENSP00000365713
- ENST00000376531
- ENSP00000365714
- ENST00000611133
- ENSP00000480177
- ENSG00000276887
- ENST00000611471
- ENSP00000484881
- ENSG00000275650
- ENST00000611711
- ENSP00000484774
- ENST00000614387
- ENSP00000484077
- ENST00000614458
- ENSP00000484835
- ENST00000616929
- ENSP00000479779
- ENSG00000276537
- ENST00000619450
- ENSP00000480769
- ENST00000619453
- ENSP00000484548
- ENST00000619591
- ENSP00000481601
- ENST00000620133
- ENSP00000483288
- ENST00000620298
- ENSP00000481138
- ENST00000622771
- ENSP00000482372
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
cellular component | 0.81 | ||
tissue sample | 0.67 | ||
PubMedID | 0.62 | ||
disease perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.56 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.56 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0