TTPA
Alpha-tocopherol transfer protein
Protein Summary
Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
- ENST00000260116
- ENSP00000260116
- ENSG00000137561
- TPP1
- ATTP
- AVED
- TTP1
- alphaTTP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.72 | ||
molecular function | 0.63 | ||
cell type or tissue | 0.61 | ||
kinase perturbation | 0.6 | ||
microRNA | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 305.4 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 305.4 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (31)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of fat-soluble vitamins | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Vitamin E | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of fat-soluble vitamins | ||||
Metabolism of vitamins and cofactors | ||||
Vitamin E | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (4)
Components (2)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (0)
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IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | alpha tocopherol transfer protein | VGNC:10488 | 472778 | |||||
Mouse | MGI:1354168 | 50500 | ||||||
Rat | RGD:3915 | 25571 | ||||||
Dog | alpha tocopherol transfer protein | VGNC:47981 | 403627 | |||||
Horse | alpha tocopherol transfer protein [Source:HGNC Symbol;Acc:HGNC:12404] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | alpha tocopherol transfer protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | alpha tocopherol transfer protein | |||||
Horse | alpha tocopherol transfer protein [Source:HGNC Symbol;Acc:HGNC:12404] | |||||
Publication Statistics
PubMed Score 305.40
PubMed score by year
PubTator Score 101.26
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (25)
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