Protein Summary
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobu ...more
- ENST00000342992
- ENSP00000343764
- ENSG00000155657
- ENST00000359218
- ENSP00000352154
- ENST00000360870
- ENSP00000354117
- ENST00000460472
- ENSP00000434586
- ENST00000591111
- ENSP00000465570
- ENST00000615779
- ENSP00000483597
- TMD
- CMH9
- CMD1G
- CMPD4
- EOMFC
- HMERF
- MYLK5
- SALMY
- LGMD2J
- LGMDR10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
protein domain | 1 | ||
interacting protein | 0.99 | ||
trait | 0.93 | ||
biological process | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2641.3 (req: < 5)
Gene RIFs: 165 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2641.3 (req: >= 5)
Gene RIFs: 165 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (265)
TLE3
Novelty: 0.02641884
p_int: 0.999998429
p_ni: 0.00000157
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
MECOM
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.99998445
p_ni: 0.00001555
Data Source: BioPlex
ADAM2
Family: Enzyme
Novelty: 0.00586482
p_int: 0.886070245
p_ni: 0.104480554
p_wrong: 0.009449201
Score: 0.426
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (6)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Muscle contraction | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Response to elevated platelet cytosolic Ca2+ | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Muscle contraction | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Response to elevated platelet cytosolic Ca2+ | ||||
Viral Interactions (0)
Gene Ontology Terms (46)
Functions (16)
Components (9)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 2 | 4 | 91.3 | |||||
3 | 3 | 0 | 1.1 | 90.9 | |||||
heart rate | 2 | 2 | 1 | 2.4 | 88.8 | ||||
heart rate response to recovery post exercise | 2 | 2 | 3 | 68.1 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 8.1 | 65.6 | ||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 4 | 91.3 | |||||
0 | 1.1 | 90.9 | |||||
heart rate | 1 | 2.4 | 88.8 | ||||
heart rate response to recovery post exercise | 3 | 68.1 | |||||
aspartate aminotransferase measurement | 0 | 8.1 | 65.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (3)
Publication Statistics
PubMed Score 2641.30
PubMed score by year
PubTator Score 1157.13
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (247)
GeneRif Annotations (165)
Items per page:
0 of 0
PMID | Year | Title |
|---|