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Tdark
TTLL6
Tubulin polyglutamylase TTLL6

Protein Summary
Description
Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
tissue sample
0.67
cell type or tissue
0.59
cell line
0.57
phenotype
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
AGBL4
Tbio
Family:  Enzyme
Novelty:  0.06139701
Score:  0.798
Data Source:  STRINGDB
CEP41
Tbio
Novelty:  0.29561674
Score:  0.713
Data Source:  STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
Score:  0.68
Data Source:  STRINGDB
AGBL5
Tbio
Family:  Enzyme
Novelty:  0.05735805
Score:  0.666
Data Source:  STRINGDB
SPAST
Tbio
Novelty:  0.00303236
Score:  0.592
Data Source:  STRINGDB
DRC1
Tbio
Novelty:  0.29125683
Score:  0.559
Data Source:  STRINGDB
HYDIN
Tbio
Novelty:  0.03318399
Score:  0.554
Data Source:  STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.553
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.552
Data Source:  STRINGDB
CCDC65
Tdark
Novelty:  0.05107666
Score:  0.552
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1
0
4
92.7
type 2 diabetes mellitus
3
3
1
1.1
89.3
1
1
0
1.1
82
appendicular lean mass
2
3
3
80.7
body height
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4
92.7
type 2 diabetes mellitus
1
1.1
89.3
0
1.1
82
appendicular lean mass
3
80.7
body height
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 6
VGNC:9750
468294
Macaque
tubulin tyrosine ligase like 6
697698
Mouse
MGI:2683461
237930
Rat
RGD:1311922
287646
Dog
tubulin tyrosine ligase like 6
VGNC:47977
480544
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 6
Macaque
tubulin tyrosine ligase like 6
Mouse
Rat
Dog
tubulin tyrosine ligase like 6
Publication Statistics
PubMed Score 8.54
PubMed score by year
PubTator Score 3.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title