Tdark TTLL11 Tubulin polyglutamylase TTLL11

Protein Summary

Description

Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity).

Uniprot Accession IDs

• Q8NHH1
• F8W6M1

Gene Name

• TTLL11

Ensembl ID

• ENST00000321582
• ENSP00000321346
• ENSG00000175764
• ENST00000373776
• ENSP00000362881

Symbol

• C9orf20
• C9orf20
• bA244O19.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.72
tissue sample	0.67
histone modification site profile	0.64
transcription factor	0.62
transcription factor perturbation	0.54

Protein Classes

PANTHER Classes

Protein / Ligase / Tubulin Polyglutamylase Ttll11

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin Polyglutamylase Ttll11

DTO Classes

Protein / Enzyme / Ligase / Tubulin Polyglutamylase Ttll11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.41   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.41   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0