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Tchem
TTL
Tubulin--tyrosine ligase

Protein Summary
Description
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233336
  • ENSP00000233336
  • ENSG00000114999
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.93
molecular function
0.86
cellular component
0.73
microRNA
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (50)
POMC
Tbio
Novelty:  0.00002436
p_int:  0.999999571
p_ni:  3.95e-7
p_wrong:  3.4e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999998702
p_ni:  0.000001294
p_wrong:  4e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
MARVELD2
Tbio
Novelty:  0.01228406
p_int:  0.999998646
p_ni:  7.01e-7
p_wrong:  6.54e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
LCP1
Tbio
Novelty:  0.0035357
p_int:  0.999918893
p_ni:  0.000052463
p_wrong:  0.000028644
Score:  0.282
Data Source:  BioPlex,STRINGDB
IL17B
Tbio
Novelty:  0.02825795
p_int:  0.99381464
p_ni:  0.006170764
p_wrong:  0.000014595
Data Source:  BioPlex
TUBB2A
Tclin
Novelty:  0.00902924
Score:  0.945
Data Source:  STRINGDB
TUBA1A
Tchem
Novelty:  0.01030145
Score:  0.94
Data Source:  STRINGDB
TUBB4A
Tclin
Novelty:  0.00045092
Score:  0.938
Data Source:  STRINGDB
A6NNZ2
Tdark
Novelty:  24
Score:  0.934
Data Source:  STRINGDB
TUBB4B
Tclin
Novelty:  0.04120134
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
3
81.8
smoking initiation
1
1
1
44.2
smoking behaviour measurement
1
1
1
36.5
sex hormone-binding globulin measurement
1
1
1
35
smoking behavior
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
81.8
smoking initiation
1
44.2
smoking behaviour measurement
1
36.5
sex hormone-binding globulin measurement
1
35
smoking behavior
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase
VGNC:10803
470483
Mouse
MGI:1916987
69737
Rat
RGD:621113
171572
Dog
tubulin tyrosine ligase
VGNC:47972
483065
Horse
tubulin tyrosine ligase
VGNC:24643
100052052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase
Mouse
Rat
Dog
tubulin tyrosine ligase
Horse
tubulin tyrosine ligase
Publication Statistics
PubMed Score 23.86
PubMed score by year
PubTator Score 89.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title