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Tbio
TTF2
Transcription termination factor 2

Protein Summary
Description
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369466
  • ENSP00000358478
  • ENSG00000116830

Symbol
  • HuF2
  • ZGRF6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.9
histone modification site profile
0.87
protein domain
0.85
cell type or tissue
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
HDAC7
Tclin
Family:  Epigenetic
Novelty:  0.00600484
p_int:  0.99995769
p_ni:  0.00004231
Score:  0.216
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999568459
p_ni:  0.000431541
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.995546489
p_ni:  0.004453511
Data Source:  BioPlex
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.989669659
p_ni:  0.010330341
Data Source:  BioPlex
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.982153915
p_ni:  0.017846085
Score:  0.204
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.98088801
p_ni:  0.01911199
Data Source:  BioPlex
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.978715319
p_ni:  0.021284681
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.975457918
p_ni:  0.024542082
Data Source:  BioPlex
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.940091145
p_ni:  0.059908855
Data Source:  BioPlex
RAD9B
Tdark
Novelty:  0.38973762
p_int:  0.924907178
p_ni:  0.075092822
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
3
1.1
88.9
neutrophil count
2
1
2
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
88.9
neutrophil count
2
17.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription termination factor 2
VGNC:10502
457157
Macaque
transcription termination factor 2
711312
Mouse
MGI:1921294
74044
Rat
RGD:1309145
295324
Dog
transcription termination factor 2
VGNC:47968
100684320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription termination factor 2
Macaque
transcription termination factor 2
Mouse
Rat
Dog
transcription termination factor 2
Publication Statistics
PubMed Score 5.50
PubMed score by year
PubTator Score 1310.09
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title