Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

TTC9C

Ensembl ID

ENST00000316461
ENSP00000325266
ENSG00000162222
ENST00000532583
ENSP00000434340

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91

virus perturbation	0.88

transcription factor binding site profile	0.84

cell type or tissue	0.8

protein domain	0.73

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94 (req: < 5)

View Publications

Gene RIFs: 1 (req: <= 3)

View Gene RIFs

Antibodies: 98 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94 (req: >= 5)

Gene RIFs: 1 (req: > 3)

Antibodies: 98 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (94)

Explore Interacting Targets

1 – 10 of 94

See Interactions on String-DB

FBXO38

Tbio

Novelty: 0.06588101

p_int: 0.999999928

p_ni: 7.2e-8

Data Source: BioPlex

NADSYN1

Tbio

Family: Enzyme

Novelty: 0.0445844

p_int: 0.999999834

p_ni: 2e-8

p_wrong: 1.46e-7

Data Source: BioPlex

FBXO10

Tbio

Novelty: 0.18324932

p_int: 0.999996866

p_ni: 0.000003134

Data Source: BioPlex

FBH1

Tbio

Family: Enzyme

Novelty: 0.04243458

p_int: 0.999995919

p_ni: 0.000003496

p_wrong: 5.85e-7

Data Source: BioPlex

FAM172A

Tbio

Novelty: 0.1200899

p_int: 0.999995912

p_ni: 0.000004088

Data Source: BioPlex

CUL7

Tbio

Novelty: 0.02183958

p_int: 0.999992926

p_ni: 0.000007075

Data Source: BioPlex

FBXW2

Tbio

Novelty: 0.01492058

p_int: 0.999949095

p_ni: 0.000049814

p_wrong: 0.000001091

Data Source: BioPlex

FBXL18

Tdark

Novelty: 0.33137957

p_int: 0.99993134

p_ni: 0.000068474

p_wrong: 1.86e-7

Data Source: BioPlex

HSP90AA4P

Tdark

p_int: 0.999868983

p_ni: 0.000100114

p_wrong: 0.000030903

Data Source: BioPlex

FBXL14

Tbio

Novelty: 0.21211079

p_int: 0.999849473

p_ni: 0.000150527

Score: 0.187

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations (null)

No disease associations found

GWAS Traits (10)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
waist-hip ratio	EFO_0004343	1	4	4	84.9

BMI-adjusted waist-hip ratio	EFO_0007788	1	4	4	84

self reported educational attainment	EFO_0004784	1	1	1	63.7

mathematical ability	EFO_0004875	1	1	1	50.6

waist circumference	EFO_0004342	1	1	1	49.5

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
waist-hip ratio	EFO_0004343	4	84.9

BMI-adjusted waist-hip ratio	EFO_0007788	4	84

self reported educational attainment	EFO_0004784	1	63.7

mathematical ability	EFO_0004875	1	50.6

waist circumference	EFO_0004342	1	49.5

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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No Header	No Header
BMI-adjusted waist circumference

BMI-adjusted waist-hip ratio

cognitive function measurement

hip circumference

mathematical ability

neutrophil percentage of leukocytes

self reported educational attainment

smoking status measurement

waist circumference

waist-hip ratio

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	tetratricopeptide repeat domain 9C	VGNC:957	466638

Mouse	tetratricopeptide repeat domain 9C	MGI:1917637	70387

Rat	tetratricopeptide repeat domain 9C	RGD:1359253	309196

Dog	tetratricopeptide repeat domain 9C	VGNC:47966	483782

Horse	tetratricopeptide repeat domain 9C	VGNC:24638	100146759

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tetratricopeptide repeat domain 9C

Mouse	tetratricopeptide repeat domain 9C

Rat	tetratricopeptide repeat domain 9C

Dog	tetratricopeptide repeat domain 9C

Horse	tetratricopeptide repeat domain 9C

Publication Statistics

PubMed Score 0.94

PubMed score by year

Related Publications

Text Mined References (5)

GeneRif Annotations (1)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Alternative splicing

Complete proteome

Reference proteome

Repeat

TPR repeat