You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TTC7B
Tetratricopeptide repeat protein 7B

Protein Summary
Description
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328459
  • ENSP00000336127
  • ENSG00000165914

Symbol
  • TTC7L1
  • TTC7L1
  • c14_5685
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
cell line
0.63
cell type or tissue
0.61
trait
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
C2orf50
Tdark
p_int:  0.999999825
p_ni:  1.72e-7
p_wrong:  3e-9
Data Source:  BioPlex
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999999695
p_ni:  3.05e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
CD226
Tbio
Novelty:  0.00374102
p_int:  0.999381587
p_ni:  0.000239912
p_wrong:  0.0003785
Data Source:  BioPlex
FAM126A
Tbio
Novelty:  0.0250547
Score:  0.946
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.935
Data Source:  STRINGDB
EFR3B
Tbio
Novelty:  0.61495463
Score:  0.842
Data Source:  STRINGDB
FAM126B
Tdark
Novelty:  0.97869796
Score:  0.822
Data Source:  STRINGDB
TEX2
Tbio
Novelty:  0.07679544
Score:  0.751
Data Source:  STRINGDB
DDX24
Tbio
Family:  Enzyme
Novelty:  0.17803446
Score:  0.731
Data Source:  STRINGDB
NKIRAS1
Tbio
Family:  Enzyme
Novelty:  0.11289799
Score:  0.72
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
1
1
0
1.1
45.8
bone density
1
1
1
23.7
gut microbiome measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
0
1.1
45.8
bone density
1
23.7
gut microbiome measurement
1
4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 7B
VGNC:12397
453101
Macaque
tetratricopeptide repeat domain 7B
696029
Mouse
MGI:2144724
104718
Rat
RGD:1305920
362768
Dog
tetratricopeptide repeat domain 7B
VGNC:47962
480417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 7B
Macaque
tetratricopeptide repeat domain 7B
Mouse
Rat
Dog
tetratricopeptide repeat domain 7B
Publication Statistics
PubMed Score 5.57
PubMed score by year
PubTator Score 2.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title