Tbio TTC4 Tetratricopeptide repeat protein 4

Protein Summary

Description

This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• O95801
• Q53Y95
• Q5TA96
• Q9H3I2
• TPR repeat protein 4

Gene Name

• TTC4

Ensembl ID

• ENST00000371281
• ENSP00000360329
• ENSG00000243725

Symbol

• CNS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
kinase perturbation	0.81
transcription factor perturbation	0.74
transcription factor binding site profile	0.63
cellular component	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.42   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.42   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0