Tbio TTC26 Intraflagellar transport protein 56

Protein Summary

Description

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.

Uniprot Accession IDs

• A0AVF1
• A4D1S3
• B7Z5M0
• C9J2N7
• F8W724
• Q9H9S8
• Q9NTC0

Gene Name

• TTC26

Ensembl ID

• ENST00000343187
• ENSP00000339135
• ENSG00000105948
• ENST00000430935
• ENSP00000410655
• ENST00000464848
• ENSP00000419279

Symbol

• IFT56
• DYF13
• IFT56
• dyf-13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
transcription factor binding site profile	0.72
virus perturbation	0.72
cellular component	0.67
cell type or tissue	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.57   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.57   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0