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Tbio
TTC19
Tetratricopeptide repeat protein 19, mitochondrial

Protein Summary
Description
Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 (PubMed:21278747, PubMed:28673544). Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity (PubMed:28673544). This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alte ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.98
transcription factor binding site profile
0.77
transcription factor perturbation
0.74
interacting protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
GPANK1
Tbio
Novelty:  0.20285376
p_int:  0.999992068
p_ni:  0.000007932
Score:  0.21
Data Source:  BioPlex,STRINGDB
EXT2
Tbio
Family:  Enzyme
Novelty:  0.00480574
p_int:  0.999906537
p_ni:  0.000093443
p_wrong:  2e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999904633
p_ni:  0.000095366
p_wrong:  1e-9
Data Source:  BioPlex
HBB
Tbio
Novelty:  0.00049683
p_int:  0.999533557
p_ni:  0.000466443
Data Source:  BioPlex
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
p_int:  0.999060807
p_ni:  0.000939193
Data Source:  BioPlex
PLA2G2D
Tchem
Family:  Enzyme
Novelty:  0.01212618
p_int:  0.998930789
p_ni:  0.001069211
Data Source:  BioPlex
BPHL
Tbio
Family:  Enzyme
Novelty:  0.03437536
p_int:  0.997045953
p_ni:  0.002954047
Score:  0.211
Data Source:  BioPlex,STRINGDB
HBG2
Tbio
Novelty:  0.01145628
p_int:  0.996940154
p_ni:  0.003059846
Data Source:  BioPlex
CMPK1
Tchem
Family:  Kinase
Novelty:  0.01478492
p_int:  0.99596964
p_ni:  0.00403036
Score:  0.554
Data Source:  BioPlex,STRINGDB
MMP19
Tbio
Family:  Enzyme
Novelty:  0.01407961
p_int:  0.991021236
p_ni:  0.008978764
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
72.5
sex hormone-binding globulin measurement
1
1
1
57.3
lymphocyte count
1
1
1
50.5
vital capacity
1
1
1
44.7
bilirubin measurement
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
72.5
sex hormone-binding globulin measurement
1
57.3
lymphocyte count
1
50.5
vital capacity
1
44.7
bilirubin measurement
1
35.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 19
VGNC:14549
455011
Macaque
tetratricopeptide repeat domain 19
700653
Mouse
MGI:1920045
72795
Rat
RGD:1582808
691506
Dog
tetratricopeptide repeat domain 19
VGNC:47941
479516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 19
Macaque
tetratricopeptide repeat domain 19
Mouse
Rat
Dog
tetratricopeptide repeat domain 19
Publication Statistics
PubMed Score 15.13
PubMed score by year
PubTator Score 11.76
PubTator score by year
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Related Publications
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PMID
Year
Title