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Tdark
TTC17
Tetratricopeptide repeat protein 17

Protein Summary
Description
Plays a role in primary ciliogenesis by modulating actin polymerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000039989
  • ENSP00000039989
  • ENSG00000052841
  • ENST00000299240
  • ENSP00000299240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.96
disease perturbation
0.87
transcription factor perturbation
0.74
histone modification site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999433329
p_ni:  0.000566671
Data Source:  BioPlex
LYZL1
Tbio
Family:  Enzyme
Novelty:  0.10945096
p_int:  0.998088946
p_ni:  0.001911054
Data Source:  BioPlex
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.992280635
p_ni:  0.007719365
Data Source:  BioPlex
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.988776567
p_ni:  0.011223433
Data Source:  BioPlex
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.984477929
p_ni:  0.015522071
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.974434748
p_ni:  0.025565252
Data Source:  BioPlex
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.972803524
p_ni:  0.027196476
Data Source:  BioPlex
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
p_int:  0.968787854
p_ni:  0.031212146
Data Source:  BioPlex
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
p_int:  0.967403573
p_ni:  0.032596427
Data Source:  BioPlex
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
p_int:  0.963435531
p_ni:  0.036564469
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
3
2
3
69.6
refractive error measurement
2
2
1
5.5
37.5
mathematical ability
1
1
1
33.1
tobacco smoke exposure measurement
1
1
1
8.6
Myopia
1
1
0
5.5
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
3
69.6
refractive error measurement
1
5.5
37.5
mathematical ability
1
33.1
tobacco smoke exposure measurement
1
8.6
Myopia
0
5.5
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 17
VGNC:950
740868
Macaque
tetratricopeptide repeat domain 17
716254
Mouse
MGI:1921819
74569
Rat
RGD:1305410
311224
Dog
tetratricopeptide repeat domain 17
VGNC:47940
475940
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 17
Macaque
tetratricopeptide repeat domain 17
Mouse
Rat
Dog
tetratricopeptide repeat domain 17
Publication Statistics
PubMed Score 2.69
PubMed score by year
PubTator Score 2.08
PubTator score by year
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Related Publications
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PMID
Year
Title