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Tbio
TTC1
Tetratricopeptide repeat protein 1

Protein Summary
Description
This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231238
  • ENSP00000231238
  • ENSG00000113312
  • ENST00000522793
  • ENSP00000429225

Symbol
  • TPR1
  • TPR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor binding site profile
0.77
disease perturbation
0.68
virus perturbation
0.68
histone modification site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.79   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.79   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
SPSB2
Tbio
Novelty:  0.07223184
p_int:  0.999999927
p_ni:  7.3e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999974282
p_ni:  0.000025717
p_wrong:  1e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.9998857
p_ni:  0.0001143
Score:  0.171
Data Source:  BioPlex,STRINGDB
LIMK2
Tchem
Family:  Kinase
Novelty:  0.0153308
p_int:  0.998995247
p_ni:  0.001004753
Score:  0.187
Data Source:  BioPlex,STRINGDB
SYT11
Tbio
Novelty:  0.02472551
p_int:  0.990779186
p_ni:  0.009220814
Score:  0.282
Data Source:  BioPlex,STRINGDB
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.959695055
p_ni:  0.040304945
Score:  0.188
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.952518779
p_ni:  0.047481221
Data Source:  BioPlex
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.895968933
p_ni:  0.104031067
Score:  0.724
Data Source:  BioPlex,STRINGDB
PCCA
Tbio
Family:  Enzyme
Novelty:  0.00515417
p_int:  0.871506359
p_ni:  0.128493633
p_wrong:  8e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.790481548
p_ni:  0.209518259
p_wrong:  1.93e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
2
3
59.1
hemoglobin measurement
3
2
3
50.4
red blood cell density measurement
1
1
1
13.5
body weight
1
1
1
12.1
heel bone mineral density
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
59.1
hemoglobin measurement
3
50.4
red blood cell density measurement
1
13.5
body weight
1
12.1
heel bone mineral density
1
9.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 1
VGNC:4213
736912
Macaque
tetratricopeptide repeat domain 1
695225
Mouse
MGI:1914077
66827
Rat
RGD:1359604
287208
Dog
tetratricopeptide repeat domain 1
VGNC:47936
489152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 1
Macaque
tetratricopeptide repeat domain 1
Mouse
Rat
Dog
tetratricopeptide repeat domain 1
Publication Statistics
PubMed Score 87.79
PubMed score by year
PubTator Score 28.94
PubTator score by year
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Related Publications
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PMID
Year
Title