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Tbio
TTBK2
Tau-tubulin kinase 2

Protein Summary
Description
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267890
  • ENSP00000267890
  • ENSG00000128881
  • ENST00000567840
  • ENSP00000455734

Symbol
  • KIAA0847
  • TTBK
  • SCA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.86
cellular component
0.77
interacting protein
0.72
cell type or tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.71   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.71   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
CEP164
Tbio
Novelty:  0.04775724
Score:  0.977
Data Source:  STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.973
Data Source:  STRINGDB
CEP97
Tbio
Novelty:  0.12709162
Score:  0.971
Data Source:  STRINGDB
CEP83
Tdark
Novelty:  0.15704554
Score:  0.97
Data Source:  STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
Score:  0.967
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.966
Data Source:  STRINGDB
FBF1
Tbio
Novelty:  0.0409747
Score:  0.961
Data Source:  STRINGDB
C2CD3
Tbio
Novelty:  0.10910688
Score:  0.959
Data Source:  STRINGDB
KIF24
Tbio
Novelty:  0.13497665
Score:  0.957
Data Source:  STRINGDB
OFD1
Tbio
Novelty:  0.01032841
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
5
92.7
high density lipoprotein cholesterol measurement
1
1
2
58.1
serum gamma-glutamyl transferase measurement
1
1
1
54.5
testosterone measurement
1
1
0
1.3
53.5
appendicular lean mass
1
1
1
49.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
92.7
high density lipoprotein cholesterol measurement
2
58.1
serum gamma-glutamyl transferase measurement
1
54.5
testosterone measurement
0
1.3
53.5
appendicular lean mass
1
49.1
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tau tubulin kinase 2
VGNC:13434
453368
Macaque
tau tubulin kinase 2
712249
Mouse
MGI:2155779
140810
Rat
RGD:1311661
311349
Dog
tau tubulin kinase 2
VGNC:47935
487520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tau tubulin kinase 2
Macaque
tau tubulin kinase 2
Mouse
Rat
Dog
tau tubulin kinase 2
Publication Statistics
PubMed Score 43.71
PubMed score by year
PubTator Score 27.36
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title