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Tbio
TSTA3
GDP-L-fucose synthase

Protein Summary
Description
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425753
  • ENSP00000398803
  • ENSG00000104522
  • ENST00000529064
  • ENSP00000435386
  • ENST00000612580
  • ENSP00000478042
  • ENSG00000278243
  • ENST00000633782
  • ENSP00000487640

Symbol
  • SDR4E1
  • FX
  • P35B
  • SDR4E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.91
disease perturbation
0.74
tissue sample
0.73
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
92.3
red blood cell distribution width
3
2
3
92.3
metabolite measurement
1
1
1
82.8
metabolite measurement
1
1
1
82.8
C-reactive protein measurement
2
2
2
75.9
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
92.3
red blood cell distribution width
3
92.3
metabolite measurement
1
82.8
metabolite measurement
1
82.8
C-reactive protein measurement
2
75.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tissue specific transplantation antigen P35B
464445
Macaque
tissue specific transplantation antigen P35B
698005
Mouse
MGI:98857
22122
Rat
RGD:1307028
300036
Dog
tissue specific transplantation antigen P35B
VGNC:47933
475116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tissue specific transplantation antigen P35B
Macaque
tissue specific transplantation antigen P35B
Mouse
Rat
Dog
tissue specific transplantation antigen P35B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13630-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
GDP-fucose biosynthesis
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
GDP-fucose biosynthesis
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (63)
1 – 10 of 63
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.96712849
p_ni:  0.016991378
p_wrong:  0.015880132
Score:  0.516
Data Source:  BioPlex,STRINGDB
GMDS
Tbio
Family:  Enzyme
Novelty:  0.00622275
Score:  0.999
Data Source:  STRINGDB
FPGT
Tbio
Family:  Enzyme
Novelty:  0.05687992
Score:  0.979
Data Source:  STRINGDB
FUK
Tbio
Family:  Kinase
Novelty:  0.05169095
Score:  0.874
Data Source:  STRINGDB
MAT2B
Tbio
Family:  Enzyme
Novelty:  0.04553044
Score:  0.869
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.85
Data Source:  STRINGDB
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.794
Data Source:  STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
Score:  0.72
Data Source:  STRINGDB
SLC35C1
Tbio
Family:  Transporter
Novelty:  0.05958023
Score:  0.7
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.696
Data Source:  STRINGDB
Publication Statistics
PubMed Score  26.81

PubMed score by year
PubTator Score  13.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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