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Tchem
TST
Thiosulfate sulfurtransferase

Protein Summary
Description
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249042
  • ENSP00000249042
  • ENSG00000128311
  • ENST00000403892
  • ENSP00000385828
  • ENST00000622841
  • ENSP00000478739

Symbol
  • RDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.98
virus perturbation
0.85
histone modification site profile
0.78
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
Score:  0.989
Data Source:  STRINGDB
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
Score:  0.982
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.981
Data Source:  STRINGDB
SQOR
Tchem
Family:  Enzyme
Novelty:  0.00291617
Score:  0.974
Data Source:  Reactome,STRINGDB
ETHE1
Tbio
Family:  Enzyme
Novelty:  0.01397214
Score:  0.972
Data Source:  STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.957
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.954
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.932
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.931
Data Source:  STRINGDB
SETBP1
Tbio
Novelty:  0.00304173
Score:  0.86
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfide oxidation to sulfate
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfide oxidation to sulfate
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
8
12
17
99.9
hemoglobin measurement
15
8
18
99.7
mean corpuscular volume
10
5
12
98.8
HbA1c measurement
8
9
14
98.7
mean corpuscular hemoglobin concentration
12
4
12
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
17
99.9
hemoglobin measurement
18
99.7
mean corpuscular volume
12
98.8
HbA1c measurement
14
98.7
mean corpuscular hemoglobin concentration
12
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thiosulfate sulfurtransferase
VGNC:6714
458803
Macaque
thiosulfate sulfurtransferase
698021
Mouse
MGI:98852
22117
Rat
RGD:3913
25274
Dog
thiosulfate sulfurtransferase
VGNC:47932
481275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thiosulfate sulfurtransferase
Macaque
thiosulfate sulfurtransferase
Mouse
Rat
Dog
thiosulfate sulfurtransferase
Publication Statistics
PubMed Score 450.61
PubMed score by year
PubTator Score 278.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title