Tchem TST Thiosulfate sulfurtransferase

Protein Summary

Description

Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q16762
• B3KRM1
• Q6IB06

Gene Name

• TST

Ensembl ID

• ENST00000249042
• ENSP00000249042
• ENSG00000128311
• ENST00000403892
• ENSP00000385828
• ENST00000622841
• ENSP00000478739

Symbol

• RDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.98
virus perturbation	0.85
histone modification site profile	0.78
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Thiosulfate Sulfurtransferase

Protein / Transfer/carrier Protein / Thiosulfate Sulfurtransferase

DTO Classes

Protein / Enzyme / Transferase / Thiosulfate Sulfurtransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 648.39   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 648.39   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2