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Tbio
TSSK6
Testis-specific serine/threonine-protein kinase 6

Protein Summary
Description
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585580
  • ENSP00000466477
  • ENSG00000178093
  • ENST00000587522
  • ENSP00000466056

Symbol
  • SSTK
  • CT72
  • SSTK
  • TSSK4
  • FKSG82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
transcription factor binding site profile
0.89
gene perturbation
0.76
histone modification site profile
0.74
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0