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Tchem
TSSK1B
Testis-specific serine/threonine-protein kinase 1

Protein Summary
Description
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390666
  • ENSP00000375081
  • ENSG00000212122

Symbol
  • SPOGA1
  • SPOGA4
  • STK22A
  • STK22D
  • TSSK1
  • TSK1
  • TSSK1
  • FKSG81
  • SPOGA4
  • STK22D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.73
gene perturbation
0.71
cell type or tissue
0.57
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (44)
CRYBG3
Tdark
Family:  Enzyme
Novelty:  0.24063491
p_int:  0.999998172
p_ni:  0.000001828
Score:  0.234
Data Source:  BioPlex,STRINGDB
CEP131
Tbio
Novelty:  0.02562073
p_int:  0.999983718
p_ni:  0.000016281
p_wrong:  1e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
GPHN
Tbio
Novelty:  0.0020752
p_int:  0.999925548
p_ni:  0.000074452
Score:  0.295
Data Source:  BioPlex,STRINGDB
SNX24
Tdark
Novelty:  0.20838126
p_int:  0.99744517
p_ni:  0.001190281
p_wrong:  0.00136455
Score:  0.677
Data Source:  BioPlex,STRINGDB
GAPVD1
Tbio
Family:  Enzyme
Novelty:  0.13142098
p_int:  0.968268304
p_ni:  0.031731694
p_wrong:  1e-9
Score:  0.729
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.930866466
p_ni:  0.069133534
Score:  0.157
Data Source:  BioPlex,STRINGDB
MKI67
Tbio
Novelty:  0.00580699
p_int:  0.807316875
p_ni:  0.192683125
Score:  0.261
Data Source:  BioPlex,STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.761897535
p_ni:  0.238102465
Score:  0.677
Data Source:  BioPlex,STRINGDB
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
Score:  0.829
Data Source:  STRINGDB
MFAP1
Tbio
Novelty:  0.15311456
Score:  0.64
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lip morphology measurement
1
1
1
39.6
body mass index
1
1
1
24.5
BMI-adjusted waist circumference
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lip morphology measurement
1
39.6
body mass index
1
24.5
BMI-adjusted waist circumference
1
5.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1347557
22114
Rat
RGD:1307352
288358
Dog
testis specific serine kinase 1B
486427
Horse
testis specific serine kinase 1B
VGNC:49315
100050947
Cow
testis specific serine kinase 1B
VGNC:50014
529193
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
testis specific serine kinase 1B
Horse
testis specific serine kinase 1B
Cow
testis specific serine kinase 1B
Publication Statistics
PubMed Score 49.55
PubMed score by year
PubTator Score 5.76
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title