Protein Summary
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
- ENST00000333256
- ENSP00000331087
- ENSG00000184281
- ENST00000380996
- ENSP00000370384
- ENST00000451491
- ENSP00000411224
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.92 | ||
disease perturbation | 0.74 | ||
transcription factor | 0.71 | ||
cellular component | 0.58 | ||
small molecule perturbation | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.25 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 44 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.25 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 44 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (112)
EAPP
Novelty: 0.06519266
p_int: 0.999999998
p_ni: 2e-9
Score: 0.845
Data Source: BioPlex,STRINGDB
ECD
Novelty: 0.06070487
p_int: 0.999999959
p_ni: 4.1e-8
Score: 0.848
Data Source: BioPlex,STRINGDB
AAR2
Novelty: 0.05805748
p_int: 0.999999929
p_ni: 7.1e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
CD2BP2
Novelty: 0.01440995
p_int: 0.999998878
p_ni: 0.000001122
Score: 0.839
Data Source: BioPlex,STRINGDB
GPATCH1
Novelty: 0.93318176
p_int: 0.999998147
p_ni: 0.000001853
Score: 0.789
Data Source: BioPlex,STRINGDB
SNRNP40
Novelty: 0.16791896
p_int: 0.999976217
p_ni: 0.000023783
Score: 0.858
Data Source: BioPlex,STRINGDB
CWF19L2
Novelty: 0.80210985
p_int: 0.999965477
p_ni: 0.000034523
Score: 0.571
Data Source: BioPlex,STRINGDB
PAXBP1
Novelty: 0.13631396
p_int: 0.999956125
p_ni: 0.000043875
Score: 0.603
Data Source: BioPlex,STRINGDB
SYF2
Novelty: 0.06114903
p_int: 0.999955161
p_ni: 0.000044839
Score: 0.782
Data Source: BioPlex,STRINGDB
DHX35
Family: Enzyme
Novelty: 0.26052594
p_int: 0.999887707
p_ni: 0.000112293
Score: 0.663
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (0)
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 2 | 3 | 176 | 13.2 | 97.7 | ||||
QT interval | 7 | 6 | 2 | 2.8 | 94.4 | ||||
T wave morphology measurement | 3 | 1 | 3 | 85.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 81.4 | |||||
basophil count | 2 | 2 | 2 | 81 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 176 | 13.2 | 97.7 | ||||
QT interval | 2 | 2.8 | 94.4 | ||||
T wave morphology measurement | 3 | 85.4 | |||||
mean corpuscular hemoglobin concentration | 1 | 81.4 | |||||
basophil count | 2 | 81 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tumor suppressing subtransferable candidate 4 | VGNC:958 | 100614609 | |||||
Macaque | tumor suppressing subtransferable candidate 4 | 705185 | ||||||
Mouse | MGI:1861712 | 56844 | ||||||
Rat | RGD:1307043 | 361682 | ||||||
Dog | tumor suppressing subtransferable candidate 4 | 611611 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tumor suppressing subtransferable candidate 4 | |||||
Macaque | tumor suppressing subtransferable candidate 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tumor suppressing subtransferable candidate 4 | |||||
Publication Statistics
PubMed Score 5.25
PubMed score by year
PubTator Score 1.68
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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