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Tbio
TSR1
Pre-rRNA-processing protein TSR1 homolog

Protein Summary
Description
Required during maturation of the 40S ribosomal subunit in the nucleolus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301364
  • ENSP00000301364
  • ENSG00000167721

Symbol
  • KIAA1401
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
kinase perturbation
0.96
virus perturbation
0.88
disease perturbation
0.87
hub protein
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.58   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.58   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (377)
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.999760471
p_ni:  0.000239529
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.997418866
p_ni:  0.002581134
Score:  0.99
Data Source:  BioPlex,STRINGDB
LTV1
Tbio
Novelty:  0.04050879
p_int:  0.997271094
p_ni:  0.002728906
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.995213404
p_ni:  0.004786596
Data Source:  BioPlex
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.992472833
p_ni:  0.007527167
Score:  0.994
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.986028821
p_ni:  0.013971179
Data Source:  BioPlex
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.98486824
p_ni:  0.01513176
Score:  0.995
Data Source:  BioPlex,STRINGDB
KPNB1
Tbio
Novelty:  0.01469696
p_int:  0.973679694
p_ni:  0.026320306
Score:  0.308
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.953952852
p_ni:  0.046047148
Score:  0.994
Data Source:  BioPlex,STRINGDB
PARN
Tbio
Family:  Enzyme
Novelty:  0.00738516
p_int:  0.952161085
p_ni:  0.032138909
p_wrong:  0.015700006
Score:  0.765
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
95
platelet crit
2
2
2
92.9
platelet count
2
2
2
89.9
2
2
1
1.1
80
lymphocyte count
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
95
platelet crit
2
92.9
platelet count
2
89.9
1
1.1
80
lymphocyte count
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TSR1, ribosome maturation factor
VGNC:10087
100608290
Macaque
TSR1, ribosome maturation factor
703311
Mouse
MGI:2144566
104662
Rat
RGD:2322150
100360406
Dog
pre-rRNA-processing protein TSR1 homolog
610048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TSR1, ribosome maturation factor
Macaque
TSR1, ribosome maturation factor
Mouse
Rat
Dog
pre-rRNA-processing protein TSR1 homolog
Publication Statistics
PubMed Score 58.58
PubMed score by year
PubTator Score 15.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title