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Tbio
TSPYL1
Testis-specific Y-encoded-like protein 1

Protein Summary
Description
The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368608
  • ENSP00000357597
  • ENSG00000189241

Symbol
  • TSPYL
  • TSPYL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
transcription factor binding site profile
0.78
microRNA
0.71
histone modification site profile
0.59
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.01   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.01   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TSPYL2
Tbio
Novelty:  0.03720016
p_int:  0.999999837
p_ni:  1.63e-7
Score:  0.579
Data Source:  BioPlex,STRINGDB
NAP1L3
Tbio
Novelty:  0.03907508
p_int:  0.999999837
p_ni:  1.61e-7
p_wrong:  1e-9
Score:  0.392
Data Source:  BioPlex,STRINGDB
LCA5
Tbio
Novelty:  0.0379066
p_int:  0.999966198
p_ni:  1.32e-7
p_wrong:  0.00003367
Score:  0.188
Data Source:  BioPlex,STRINGDB
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.999890454
p_ni:  0.000109546
Score:  0.154
Data Source:  BioPlex,STRINGDB
SIPA1L2
Tbio
Novelty:  0.2002618
p_int:  0.999685483
p_ni:  0.000314513
p_wrong:  4e-9
Data Source:  BioPlex
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.999473831
p_ni:  0.000526167
p_wrong:  2e-9
Data Source:  BioPlex
SPAG5
Tbio
Novelty:  0.02392116
p_int:  0.998815866
p_ni:  0.001184134
Data Source:  BioPlex
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.998749519
p_ni:  0.001239197
p_wrong:  0.000011283
Data Source:  BioPlex
ZNF687
Tbio
Family:  TF
Novelty:  0.14707532
p_int:  0.997912373
p_ni:  0.002087627
Score:  0.276
Data Source:  BioPlex,STRINGDB
DDX24
Tbio
Family:  Enzyme
Novelty:  0.17803446
p_int:  0.997752499
p_ni:  0.002247501
Score:  0.258
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Myometrial Relaxation and Contraction Pathways
WikiPathways
Cell Cycle
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Myometrial Relaxation and Contraction Pathways
Cell Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
44.2
electroencephalogram measurement
1
1
1
17.8
alcohol dependence measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
44.2
electroencephalogram measurement
1
17.8
alcohol dependence measurement
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TSPY like 1
VGNC:12737
472103
Mouse
MGI:1298395
22110
Rat
RGD:1307726
29544
Horse
TSPY like 1
VGNC:51089
100072651
Cow
TSPY like 1
VGNC:53811
538541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TSPY like 1
Mouse
Rat
Horse
TSPY like 1
Cow
TSPY like 1
Publication Statistics
PubMed Score 14.01
PubMed score by year
PubTator Score 7.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title