Protein Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
- ENST00000373020
- ENSP00000362111
- ENSG00000000003
- TM4SF6
- T245
- TM4SF6
- TSPAN-6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.87 | ||
microRNA | 0.64 | ||
histone modification site profile | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.97 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.97 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (51)
EVA1C
Novelty: 0.45928677
p_int: 0.996497676
p_ni: 0.001306142
p_wrong: 0.002196181
Score: 0.158
Data Source: BioPlex,STRINGDB
CLEC5A
Novelty: 0.01710591
p_int: 0.989473542
p_ni: 0.002558156
p_wrong: 0.007968302
Score: 0.204
Data Source: BioPlex,STRINGDB
ASIC4
Family: IC
Novelty: 0.02912816
p_int: 0.987749717
p_ni: 0.012242557
p_wrong: 0.000007726
Data Source: BioPlex
SERPINA12
Novelty: 0.00549132
p_int: 0.98734677
p_ni: 0.01264158
p_wrong: 0.00001165
Data Source: BioPlex
TNFRSF17
Novelty: 0.00222663
p_int: 0.984894402
p_ni: 0.007555902
p_wrong: 0.007549696
Score: 0.163
Data Source: BioPlex,STRINGDB
GPR141
Family: GPCR
Novelty: 0.30711523
p_int: 0.979303184
p_ni: 0.020686341
p_wrong: 0.000010476
Score: 0.173
Data Source: BioPlex,STRINGDB
LYPD4
Novelty: 0.00381728
p_int: 0.978295779
p_ni: 0.003343311
p_wrong: 0.018360911
Data Source: BioPlex
TMEM185A
Novelty: 0.0262898
p_int: 0.975744121
p_ni: 0.004714567
p_wrong: 0.019541312
Data Source: BioPlex
TMEM30B
Novelty: 0.26735006
p_int: 0.975744121
p_ni: 0.004714567
p_wrong: 0.019541312
Data Source: BioPlex
VNN2
Novelty: 0.02286648
p_int: 0.971222858
p_ni: 0.003925409
p_wrong: 0.024851733
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (6)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 2 | 2 | 2 | 68.5 | |||||
mean platelet volume | 1 | 1 | 1 | 60.2 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 2 | 68.5 | |||||
mean platelet volume | 1 | 60.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tetraspanin 6 | VGNC:11609 | 473698 | |||||
Macaque | tetraspanin 6 | 703166 | ||||||
Mouse | MGI:1926264 | 56496 | ||||||
Rat | RGD:1560160 | 302313 | ||||||
Dog | tetraspanin 6 | VGNC:47924 | 480981 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tetraspanin 6 | |||||
Macaque | tetraspanin 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tetraspanin 6 | |||||
Publication Statistics
PubMed Score 8.97
PubMed score by year
PubTator Score 5.89
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
---|