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Tbio
TSPAN6
Tetraspanin-6

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373020
  • ENSP00000362111
  • ENSG00000000003

Symbol
  • TM4SF6
  • T245
  • TM4SF6
  • TSPAN-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.91
disease perturbation
0.87
microRNA
0.64
histone modification site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.97   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.97   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
EVA1C
Tbio
Novelty:  0.45928677
p_int:  0.996497676
p_ni:  0.001306142
p_wrong:  0.002196181
Score:  0.158
Data Source:  BioPlex,STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
p_int:  0.989473542
p_ni:  0.002558156
p_wrong:  0.007968302
Score:  0.204
Data Source:  BioPlex,STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.987749717
p_ni:  0.012242557
p_wrong:  0.000007726
Data Source:  BioPlex
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.98734677
p_ni:  0.01264158
p_wrong:  0.00001165
Data Source:  BioPlex
TNFRSF17
Tclin
Novelty:  0.00222663
p_int:  0.984894402
p_ni:  0.007555902
p_wrong:  0.007549696
Score:  0.163
Data Source:  BioPlex,STRINGDB
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
p_int:  0.979303184
p_ni:  0.020686341
p_wrong:  0.000010476
Score:  0.173
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.978295779
p_ni:  0.003343311
p_wrong:  0.018360911
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.975744121
p_ni:  0.004714567
p_wrong:  0.019541312
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.975744121
p_ni:  0.004714567
p_wrong:  0.019541312
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.971222858
p_ni:  0.003925409
p_wrong:  0.024851733
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
68.5
mean platelet volume
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
68.5
mean platelet volume
1
60.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 6
VGNC:11609
473698
Macaque
tetraspanin 6
703166
Mouse
MGI:1926264
56496
Rat
RGD:1560160
302313
Dog
tetraspanin 6
VGNC:47924
480981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 6
Macaque
tetraspanin 6
Mouse
Rat
Dog
tetraspanin 6
Publication Statistics
PubMed Score 8.97
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
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PMID
Year
Title