Tbio TSPAN6 Tetraspanin-6

Protein Summary

Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O43657
• Q54A42
• Q6IAN9
• Tspan-6

Gene Name

• TSPAN6

Ensembl ID

• ENST00000373020
• ENSP00000362111
• ENSG00000000003

Symbol

• TM4SF6
• T245
• TM4SF6
• TSPAN-6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.91
disease perturbation	0.87
microRNA	0.64
histone modification site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.97   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.97   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (51)

Explore Interacting Targets

1 – 10 of 51

• See Interactions on String-DB

EVA1C

Tbio

Novelty:  0.45928677

p_int:  0.996497676

p_ni:  0.001306142

p_wrong:  0.002196181

Score:  0.158

Data Source:  BioPlex,STRINGDB

CLEC5A

Tbio

Novelty:  0.01710591

p_int:  0.989473542

p_ni:  0.002558156

p_wrong:  0.007968302

Score:  0.204

Data Source:  BioPlex,STRINGDB

ASIC4

Tbio

Family:  IC

Novelty:  0.02912816

p_int:  0.987749717

p_ni:  0.012242557

p_wrong:  0.000007726

Data Source:  BioPlex

SERPINA12

Tbio

Novelty:  0.00549132

p_int:  0.98734677

p_ni:  0.01264158

p_wrong:  0.00001165

Data Source:  BioPlex

TNFRSF17

Tclin

Novelty:  0.00222663

p_int:  0.984894402

p_ni:  0.007555902

p_wrong:  0.007549696

Score:  0.163

Data Source:  BioPlex,STRINGDB

GPR141

Tdark

Family:  GPCR

Novelty:  0.30711523

p_int:  0.979303184

p_ni:  0.020686341

p_wrong:  0.000010476

Score:  0.173

Data Source:  BioPlex,STRINGDB

LYPD4

Tbio

Novelty:  0.00381728

p_int:  0.978295779

p_ni:  0.003343311

p_wrong:  0.018360911

Data Source:  BioPlex

TMEM185A

Tdark

Novelty:  0.0262898

p_int:  0.975744121

p_ni:  0.004714567

p_wrong:  0.019541312

Data Source:  BioPlex

TMEM30B

Tbio

Novelty:  0.26735006

p_int:  0.975744121

p_ni:  0.004714567

p_wrong:  0.019541312

Data Source:  BioPlex

VNN2

Tbio

Novelty:  0.02286648

p_int:  0.971222858

p_ni:  0.003925409

p_wrong:  0.024851733

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (2)

Processes (4)

Find Similar Targets

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1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
integral component of plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	2	2	2		68.5
mean platelet volume	EFO_0004584	1	1	1		60.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	2		68.5
mean platelet volume	EFO_0004584	1		60.2

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UniProt Keyword Find Similar Targets

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Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
mean platelet volume
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 6	VGNC:11609	473698
Macaque	tetraspanin 6		703166
Mouse	tetraspanin 6	MGI:1926264	56496
Rat	tetraspanin 6	RGD:1560160	302313
Dog	tetraspanin 6	VGNC:47924	480981

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 6
Macaque	tetraspanin 6
Mouse	tetraspanin 6
Rat	tetraspanin 6
Dog	tetraspanin 6

Publication Statistics

PubMed Score 8.97

PubMed score by year

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PubTator Score 5.89

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title