Tbio TSPAN4 Tetraspanin-4

Protein Summary

Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14817
• Q6IAP6
• Tspan-4

Gene Name

• TSPAN4

Ensembl ID

• ENST00000397397
• ENSP00000380552
• ENSG00000214063
• ENST00000397404
• ENSP00000380553
• ENST00000397406
• ENSP00000380554
• ENST00000397408
• ENSP00000380555
• ENST00000397411
• ENSP00000380558
• ENST00000409543
• ENSP00000386513

Symbol

• NAG2
• TM4SF7
• NAG2
• NAG-2
• TM4SF7
• TSPAN-4
• TETRASPAN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
transcription factor	0.91
transcription factor perturbation	0.88
kinase perturbation	0.84
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.32   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.32   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0