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Tbio
TSPAN4
Tetraspanin-4

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397397
  • ENSP00000380552
  • ENSG00000214063
  • ENST00000397404
  • ENSP00000380553
  • ENST00000397406
  • ENSP00000380554
  • ENST00000397408
  • ENSP00000380555
  • ENST00000397411
  • ENSP00000380558
  • ENST00000409543
  • ENSP00000386513

Symbol
  • NAG2
  • TM4SF7
  • NAG2
  • NAG-2
  • TM4SF7
  • TSPAN-4
  • TETRASPAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
transcription factor
0.91
transcription factor perturbation
0.88
kinase perturbation
0.84
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.03   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.03   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
TM4SF4
Tbio
Novelty:  0.08609112
Score:  0.802
Data Source:  STRINGDB
LHFPL4
Tdark
Novelty:  0.60482288
Score:  0.8
Data Source:  STRINGDB
LHFPL3
Tbio
Novelty:  0.20055141
Score:  0.745
Data Source:  STRINGDB
LHFPL5
Tbio
Novelty:  0.03689538
Score:  0.719
Data Source:  STRINGDB
ASPDH
Tbio
Family:  Enzyme
Novelty:  0.10061479
Score:  0.703
Data Source:  STRINGDB
PMP22
Tbio
Novelty:  0.00256307
Score:  0.698
Data Source:  STRINGDB
PLP1
Tbio
Novelty:  0.00129083
Score:  0.675
Data Source:  STRINGDB
EMP2
Tbio
Novelty:  0.01548363
Score:  0.669
Data Source:  STRINGDB
TM4SF1
Tbio
Novelty:  0.02410436
Score:  0.655
Data Source:  STRINGDB
UPK3A
Tbio
Novelty:  0.00840631
Score:  0.652
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
91.5
mean platelet volume
2
2
2
89.4
intraocular pressure measurement
2
3
3
89
waist-hip ratio
4
6
9
86.9
2
2
1
6.6
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
91.5
mean platelet volume
2
89.4
intraocular pressure measurement
3
89
waist-hip ratio
9
86.9
1
6.6
82.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 4
VGNC:12765
450938
Mouse
MGI:1928097
64540
Rat
RGD:1305810
293627
Dog
tetraspanin 4
611422
Horse
tetraspanin 4
VGNC:24592
100055228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 4
Mouse
Rat
Dog
tetraspanin 4
Horse
tetraspanin 4
Publication Statistics
PubMed Score 32.03
PubMed score by year
PubTator Score 26.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title