Tbio TSPAN3 Tetraspanin-3

Protein Summary

Description

Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• O60637
• A6NEH4
• B3KQQ2
• B4DP19
• Q9BW22
• Q9NVX9
• Tspan-3

Gene Name

• TSPAN3

Ensembl ID

• ENST00000267970
• ENSP00000267970
• ENSG00000140391
• ENST00000346495
• ENSP00000341329
• ENST00000424443
• ENSP00000407243

Symbol

• TM4SF8
• TM4-A
• TM4SF8
• TSPAN-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.9
transcription factor perturbation	0.88
microRNA	0.8
virus perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (78)

Explore Interacting Targets

1 – 10 of 78

• See Interactions on String-DB

CC2D1A

Tbio

Novelty:  0.01970021

p_int:  0.999997388

p_ni:  0.000002611

p_wrong:  1e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

PI4K2A

Tbio

Family:  Kinase

Novelty:  0.03506675

p_int:  0.999975832

p_ni:  0.000024164

p_wrong:  4e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

UGCG

Tclin

Family:  Enzyme

Novelty:  0.00481791

p_int:  0.999551637

p_ni:  0.000322717

p_wrong:  0.000125647

Score:  0.523

Data Source:  BioPlex,STRINGDB

LRRC8B

Tbio

Novelty:  0.16457267

p_int:  0.998404003

p_ni:  0.001588558

p_wrong:  0.000007439

Data Source:  BioPlex

RDH14

Tdark

Family:  Enzyme

Novelty:  0.35816611

p_int:  0.998135042

p_ni:  0.000721267

p_wrong:  0.00114369

Score:  0.227

Data Source:  BioPlex,STRINGDB

EPHA5

Tchem

Family:  Kinase

Novelty:  0.01143252

p_int:  0.99769917

p_ni:  3.56e-7

p_wrong:  0.002300474

Score:  0.77

Data Source:  BioPlex,STRINGDB

SPPL2B

Tchem

Family:  Enzyme

Novelty:  0.0274774

p_int:  0.99734318

p_ni:  0.002655987

p_wrong:  8.33e-7

Data Source:  BioPlex

TSPAN2

Tbio

Novelty:  0.03842973

p_int:  0.997320959

p_ni:  0.002678216

p_wrong:  8.25e-7

Score:  0.23

Data Source:  BioPlex,STRINGDB

FGFR2

Tclin

Family:  Kinase

Novelty:  0.00066613

p_int:  0.997161407

p_ni:  0.002838582

p_wrong:  1.1e-8

Score:  0.207

Data Source:  BioPlex,STRINGDB

FAM189B

Tbio

Novelty:  0.21064304

p_int:  0.996924295

p_ni:  0.002952444

p_wrong:  0.000123261

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Components (2)

Processes (1)

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1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
integral component of plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	2	2		72.4
BMI-adjusted hip circumference	EFO_0008039	2	4	5		65.3
myeloid white cell count	EFO_0007988	1	1	1		59.9
self reported educational attainment	EFO_0004784	1	1	1		42.3
leukocyte count	EFO_0004308	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		72.4
BMI-adjusted hip circumference	EFO_0008039	5		65.3
myeloid white cell count	EFO_0007988	1		59.9
self reported educational attainment	EFO_0004784	1		42.3
leukocyte count	EFO_0004308	1		30.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
BMI-adjusted hip circumference
creatinine measurement
eosinophil count
glomerular filtration rate
leukocyte count
myeloid white cell count
neutrophil count
platelet crit
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 3		467832
Macaque	tetraspanin 3		708428
Mouse	tetraspanin 3	MGI:1928098	56434
Rat	tetraspanin 3	RGD:1359444	300733
Dog	tetraspanin 3	VGNC:47919	487663

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 3
Macaque	tetraspanin 3
Mouse	tetraspanin 3
Rat	tetraspanin 3
Dog	tetraspanin 3

Publication Statistics

PubMed Score 16.09

PubMed score by year

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PubTator Score 4.19

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (3)

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0 of 0

PMID	Year	Title