Protein Summary
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
- ENST00000267970
- ENSP00000267970
- ENSG00000140391
- ENST00000346495
- ENSP00000341329
- ENST00000424443
- ENSP00000407243
- TM4SF8
- TM4-A
- TM4SF8
- TSPAN-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.9 | ||
transcription factor perturbation | 0.88 | ||
microRNA | 0.8 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.09 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 154 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.09 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 154 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (78)
CC2D1A
Novelty: 0.01970021
p_int: 0.999997388
p_ni: 0.000002611
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
PI4K2A
Family: Kinase
Novelty: 0.03506675
p_int: 0.999975832
p_ni: 0.000024164
p_wrong: 4e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
UGCG
Family: Enzyme
Novelty: 0.00481791
p_int: 0.999551637
p_ni: 0.000322717
p_wrong: 0.000125647
Score: 0.523
Data Source: BioPlex,STRINGDB
LRRC8B
Novelty: 0.16457267
p_int: 0.998404003
p_ni: 0.001588558
p_wrong: 0.000007439
Data Source: BioPlex
RDH14
Family: Enzyme
Novelty: 0.35816611
p_int: 0.998135042
p_ni: 0.000721267
p_wrong: 0.00114369
Score: 0.227
Data Source: BioPlex,STRINGDB
EPHA5
Family: Kinase
Novelty: 0.01143252
p_int: 0.99769917
p_ni: 3.56e-7
p_wrong: 0.002300474
Score: 0.77
Data Source: BioPlex,STRINGDB
SPPL2B
Family: Enzyme
Novelty: 0.0274774
p_int: 0.99734318
p_ni: 0.002655987
p_wrong: 8.33e-7
Data Source: BioPlex
TSPAN2
Novelty: 0.03842973
p_int: 0.997320959
p_ni: 0.002678216
p_wrong: 8.25e-7
Score: 0.23
Data Source: BioPlex,STRINGDB
FGFR2
Family: Kinase
Novelty: 0.00066613
p_int: 0.997161407
p_ni: 0.002838582
p_wrong: 1.1e-8
Score: 0.207
Data Source: BioPlex,STRINGDB
FAM189B
Novelty: 0.21064304
p_int: 0.996924295
p_ni: 0.002952444
p_wrong: 0.000123261
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (3)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 2 | 2 | 72.4 | |||||
BMI-adjusted hip circumference | 2 | 4 | 5 | 65.3 | |||||
myeloid white cell count | 1 | 1 | 1 | 59.9 | |||||
self reported educational attainment | 1 | 1 | 1 | 42.3 | |||||
leukocyte count | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 2 | 72.4 | |||||
BMI-adjusted hip circumference | 5 | 65.3 | |||||
myeloid white cell count | 1 | 59.9 | |||||
self reported educational attainment | 1 | 42.3 | |||||
leukocyte count | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tetraspanin 3 | 467832 | ||||||
Macaque | tetraspanin 3 | 708428 | ||||||
Mouse | MGI:1928098 | 56434 | ||||||
Rat | RGD:1359444 | 300733 | ||||||
Dog | tetraspanin 3 | VGNC:47919 | 487663 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tetraspanin 3 | |||||
Macaque | tetraspanin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tetraspanin 3 | |||||
Publication Statistics
PubMed Score 16.09
PubMed score by year
PubTator Score 4.19
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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