Tbio TSPAN2 Tetraspanin-2

Protein Summary

Description

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• O60636
• D6PTH4
• Q5TET2
• Q8WU05
• Tspan-2

Gene Name

• TSPAN2

Ensembl ID

• ENST00000369516
• ENSP00000358529
• ENSG00000134198

Symbol

• NET3
• TSN2
• TSPAN-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
gene perturbation	0.82
microRNA	0.78
protein domain	0.73
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (72)

Explore Interacting Targets

1 – 10 of 72

• See Interactions on String-DB

SNX13

Tbio

Novelty:  0.12227762

p_int:  0.999999989

p_ni:  1.1e-8

Score:  0.235

Data Source:  BioPlex,STRINGDB

SNX14

Tbio

Novelty:  0.10690692

p_int:  0.999998088

p_ni:  0.000001911

p_wrong:  1e-9

Data Source:  BioPlex

PTGFRN

Tbio

Novelty:  0.02271483

p_int:  0.999995479

p_ni:  0.000004521

Score:  0.812

Data Source:  BioPlex,STRINGDB

ZDHHC6

Tbio

Family:  Enzyme

Novelty:  0.17384821

p_int:  0.999482362

p_ni:  0.000517637

p_wrong:  1e-9

Score:  0.186

Data Source:  BioPlex,STRINGDB

TSPAN3

Tbio

Novelty:  0.06362133

p_int:  0.997320959

p_ni:  0.002678216

p_wrong:  8.25e-7

Score:  0.23

Data Source:  BioPlex,STRINGDB

REEP6

Tbio

Novelty:  0.10645981

p_int:  0.989255611

p_ni:  0.01068711

p_wrong:  0.000057279

Score:  0.155

Data Source:  BioPlex,STRINGDB

TSPAN15

Tbio

Novelty:  0.16947672

p_int:  0.988430394

p_ni:  0.009793797

p_wrong:  0.001775809

Score:  0.609

Data Source:  BioPlex,STRINGDB

FAM241A

Tdark

Novelty:  1.04041354

p_int:  0.985236831

p_ni:  0.014604955

p_wrong:  0.000158215

Data Source:  BioPlex

HSDL1

Tbio

Family:  Enzyme

Novelty:  0.24066595

p_int:  0.978300396

p_ni:  0.021699598

p_wrong:  6e-9

Data Source:  BioPlex

MTCH1

Tbio

Novelty:  0.12469914

p_int:  0.975189228

p_ni:  0.024810768

p_wrong:  4e-9

Score:  0.163

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Components (3)

Processes (8)

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1 – 3 of 3

GO Term	Evidence	Assigned by
integral component of plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
integral component of membrane	Traceable Author Statement (TAS)	ProtInc
myelin sheath	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
migraine disorder	EFO_0003821	3	2	0	1.1	76.2
large artery stroke	EFO_0005524	3	2	0	1.2	36.9
migraine without aura	EFO_0005296	2	2	0	1.2	27.9
Headache	HP_0002315	1	1	1		6.9
Ischemic stroke	HP_0002140	1	1	0	1.2	5.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
migraine disorder	EFO_0003821	0	1.1	76.2
large artery stroke	EFO_0005524	0	1.2	36.9
migraine without aura	EFO_0005296	0	1.2	27.9
Headache	HP_0002315	1		6.9
Ischemic stroke	HP_0002140	0	1.2	5.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
Headache
Ischemic stroke
large artery stroke
migraine disorder
migraine without aura

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 2	VGNC:10917	457148
Macaque	tetraspanin 2		709463
Mouse	tetraspanin 2	MGI:1917997	70747
Rat	tetraspanin 2	RGD:620982	64521
Dog	tetraspanin 2	VGNC:47918	612755

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 2
Macaque	tetraspanin 2
Mouse	tetraspanin 2
Rat	tetraspanin 2
Dog	tetraspanin 2

Publication Statistics

PubMed Score 23.73

PubMed score by year

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PubTator Score 99.29

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (8)

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10

0 of 0

PMID	Year	Title