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Tbio
TSPAN2
Tetraspanin-2

Protein Summary
Description
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369516
  • ENSP00000358529
  • ENSG00000134198

Symbol
  • NET3
  • TSN2
  • TSPAN-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
gene perturbation
0.82
microRNA
0.78
protein domain
0.73
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
SNX13
Tbio
Novelty:  0.12227762
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
SNX14
Tbio
Novelty:  0.10690692
p_int:  0.999998088
p_ni:  0.000001911
p_wrong:  1e-9
Data Source:  BioPlex
PTGFRN
Tbio
Novelty:  0.02271483
p_int:  0.999995479
p_ni:  0.000004521
Score:  0.812
Data Source:  BioPlex,STRINGDB
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999482362
p_ni:  0.000517637
p_wrong:  1e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.997320959
p_ni:  0.002678216
p_wrong:  8.25e-7
Score:  0.23
Data Source:  BioPlex,STRINGDB
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.989255611
p_ni:  0.01068711
p_wrong:  0.000057279
Score:  0.155
Data Source:  BioPlex,STRINGDB
TSPAN15
Tbio
Novelty:  0.16947672
p_int:  0.988430394
p_ni:  0.009793797
p_wrong:  0.001775809
Score:  0.609
Data Source:  BioPlex,STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.985236831
p_ni:  0.014604955
p_wrong:  0.000158215
Data Source:  BioPlex
HSDL1
Tbio
Family:  Enzyme
Novelty:  0.24066595
p_int:  0.978300396
p_ni:  0.021699598
p_wrong:  6e-9
Data Source:  BioPlex
MTCH1
Tbio
Novelty:  0.12469914
p_int:  0.975189228
p_ni:  0.024810768
p_wrong:  4e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
76.2
large artery stroke
3
2
0
1.2
36.9
2
2
0
1.2
27.9
Headache
1
1
1
6.9
Ischemic stroke
1
1
0
1.2
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
76.2
large artery stroke
0
1.2
36.9
0
1.2
27.9
Headache
1
6.9
Ischemic stroke
0
1.2
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 2
VGNC:10917
457148
Macaque
tetraspanin 2
709463
Mouse
MGI:1917997
70747
Rat
RGD:620982
64521
Dog
tetraspanin 2
VGNC:47918
612755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 2
Macaque
tetraspanin 2
Mouse
Rat
Dog
tetraspanin 2
Publication Statistics
PubMed Score 23.73
PubMed score by year
PubTator Score 99.29
PubTator score by year
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Related Publications
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PMID
Year
Title