Tbio TSPAN2 Tetraspanin-2

Protein Summary

Description

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• O60636
• D6PTH4
• Q5TET2
• Q8WU05
• Tspan-2

Gene Name

• TSPAN2

Ensembl ID

• ENST00000369516
• ENSP00000358529
• ENSG00000134198

Symbol

• NET3
• TSN2
• TSPAN-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
gene perturbation	0.82
microRNA	0.78
protein domain	0.73
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.29   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.29   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0