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Tdark
TSPAN17
Tetraspanin-17

Protein Summary
Description
Regulates ADAM10 maturation. This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298564
  • ENSP00000298564
  • ENSG00000048140
  • ENST00000508164
  • ENSP00000422053
  • ENST00000515708
  • ENSP00000426650

Symbol
  • FBXO23
  • TM4SF17
  • FBX23
  • FBXO23
  • TM4SF17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
histone modification site profile
0.65
tissue sample
0.6
transcription factor
0.6
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
METTL7A
Tbio
Family:  Enzyme
Novelty:  0.10143651
p_int:  0.999994386
p_ni:  0.000005608
p_wrong:  6e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.999969471
p_ni:  0.000030178
p_wrong:  3.5e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.999662309
p_ni:  0.000334249
p_wrong:  0.000003442
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.999560054
p_ni:  0.000439944
p_wrong:  1e-9
Data Source:  BioPlex
CCDC115
Tbio
Novelty:  0.23966137
p_int:  0.999124886
p_ni:  0.000647598
p_wrong:  0.000227516
Score:  0.294
Data Source:  BioPlex,STRINGDB
GHDC
Tbio
Novelty:  0.08423152
p_int:  0.998628211
p_ni:  0.001371789
Data Source:  BioPlex
TYW1
Tbio
Family:  Enzyme
Novelty:  0.05117274
p_int:  0.994004117
p_ni:  0.005995883
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.993706599
p_ni:  0.006293401
Data Source:  BioPlex
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.98351509
p_ni:  0.016484909
p_wrong:  1e-9
Data Source:  BioPlex
GPR89A
Tbio
Family:  IC
Novelty:  0.06782776
p_int:  0.971140073
p_ni:  0.028859795
p_wrong:  1.32e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 17
VGNC:13609
462295
Mouse
MGI:1921507
74257
Rat
RGD:1311167
306771
Dog
tetraspanin 17
VGNC:47916
489098
Horse
tetraspanin 17 [Source:HGNC Symbol;Acc:HGNC:13594]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 17
Mouse
Rat
Dog
tetraspanin 17
Horse
tetraspanin 17 [Source:HGNC Symbol;Acc:HGNC:13594]
Publication Statistics
PubMed Score 2.51
PubMed score by year
PubTator Score 0.60
PubTator score by year
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Related Publications
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PMID
Year
Title