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Tbio
TSPAN15
Tetraspanin-15

Protein Summary
Description
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373290
  • ENSP00000362387
  • ENSG00000099282

Symbol
  • NET7
  • TM4SF15
  • NET7
  • NET-7
  • TM4SF15
  • 2700063A19Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
transcription factor binding site profile
0.73
gene perturbation
0.68
transcription factor
0.66
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
FZD4
Tchem
Family:  GPCR
Novelty:  0.00577957
p_int:  0.9990887
p_ni:  0.000911039
p_wrong:  2.61e-7
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.995195495
p_ni:  0.00479377
p_wrong:  0.000010735
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.989980056
p_ni:  0.009877451
p_wrong:  0.000142493
Score:  0.269
Data Source:  BioPlex,STRINGDB
TSPAN2
Tbio
Novelty:  0.03842973
p_int:  0.988430394
p_ni:  0.009793797
p_wrong:  0.001775809
Score:  0.609
Data Source:  BioPlex,STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.976274702
p_ni:  0.023725288
p_wrong:  1e-8
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.969444749
p_ni:  0.030555249
p_wrong:  2e-9
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.949057173
p_ni:  0.050716
p_wrong:  0.000226828
Data Source:  BioPlex
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.940302858
p_ni:  0.058882648
p_wrong:  0.000814495
Data Source:  BioPlex
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.929282972
p_ni:  0.068735341
p_wrong:  0.001981687
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.927471463
p_ni:  0.071799241
p_wrong:  0.000729297
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
1
1.3
95
HbA1c measurement
1
11
11
92
type 2 diabetes mellitus
6
2
3
1.1
84.8
reticulocyte measurement
3
2
3
71.7
reticulocyte count
2
2
2
71.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
95
HbA1c measurement
11
92
type 2 diabetes mellitus
3
1.1
84.8
reticulocyte measurement
3
71.7
reticulocyte count
2
71.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 15
VGNC:12515
450507
Macaque
tetraspanin 15
711675
Mouse
MGI:1917673
70423
Rat
RGD:1588304
679462
Dog
tetraspanin 15
VGNC:47915
609466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 15
Macaque
tetraspanin 15
Mouse
Rat
Dog
tetraspanin 15
Publication Statistics
PubMed Score 9.15
PubMed score by year
PubTator Score 4.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title