Tdark TSPAN11 Tetraspanin-11

Protein Summary

Uniprot Accession IDs

• A1L157
• A1L158
• B2RUX6
• Tspan-11

Gene Name

• TSPAN11

Ensembl ID

• ENST00000261177
• ENSP00000261177
• ENSG00000110900
• ENST00000546076
• ENSP00000437403

Symbol

• VSSW1971

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.77
cell line	0.69
trait	0.61
histone modification site profile	0.6
tissue sample	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (35)

Explore Interacting Targets

1 – 10 of 35

• See Interactions on String-DB

POMC

Tbio

Novelty:  0.00002436

p_int:  0.999999849

p_ni:  1.45e-7

p_wrong:  6e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

ITGA6

Tbio

Novelty:  0.00217985

p_int:  0.999972664

p_ni:  0.000027336

Score:  0.211

Data Source:  BioPlex,STRINGDB

ITGA7

Tbio

Novelty:  0.01243073

p_int:  0.999800575

p_ni:  0.000199425

Score:  0.282

Data Source:  BioPlex,STRINGDB

ESYT1

Tbio

Novelty:  0.03069611

p_int:  0.99934484

p_ni:  0.00065516

Score:  0.318

Data Source:  BioPlex,STRINGDB

CYB5R3

Tbio

Family:  Enzyme

Novelty:  0.00774258

p_int:  0.977395435

p_ni:  0.022604564

p_wrong:  1e-9

Score:  0.186

Data Source:  BioPlex,STRINGDB

IGLL5

Tbio

Novelty:  0.00459259

p_int:  0.968702038

p_ni:  0.029635891

p_wrong:  0.001662071

Score:  0.177

Data Source:  BioPlex,STRINGDB

NRP2

Tbio

Novelty:  0.00764179

p_int:  0.936551964

p_ni:  0.063445861

p_wrong:  0.000002175

Score:  0.2

Data Source:  BioPlex,STRINGDB

ARL6IP5

Tbio

Novelty:  0.00871985

p_int:  0.865502073

p_ni:  0.134497926

p_wrong:  1e-9

Data Source:  BioPlex

ITGB1

Tclin

Novelty:  0.00055626

p_int:  0.857073632

p_ni:  0.142926368

Score:  0.206

Data Source:  BioPlex,STRINGDB

REEP5

Tbio

Novelty:  0.00160455

p_int:  0.797898185

p_ni:  0.202101338

p_wrong:  4.77e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
optic disc size measurement	EFO_0004832	1	1	1		17.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
optic disc size measurement	EFO_0004832	1		17.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
optic disc size measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	tetraspanin 11		694030
Mouse	tetraspanin 11	MGI:1915748	68498
Rat	tetraspanin 11	RGD:1305424	312727
Dog	tetraspanin 11	VGNC:47911	611819
Horse	tetraspanin 11	VGNC:24587	100051003

Species	Name	OMA	EggNOG	Inparanoid
Macaque	tetraspanin 11
Mouse	tetraspanin 11
Rat	tetraspanin 11
Dog	tetraspanin 11
Horse	tetraspanin 11

Publication Statistics

PubMed Score 1.74

PubMed score by year

Reset Zoom

PubTator Score 0.05

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (4)

Items per page:

10

0 of 0

PMID	Year	Title