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Tbio
TSPAN1
Tetraspanin-1

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372003
  • ENSP00000361072
  • ENSG00000117472

Symbol
  • NET1
  • TM4C
  • TM4SF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
gene perturbation
0.72
small molecule perturbation
0.68
transcription factor perturbation
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.24   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.24   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SNX13
Tbio
Novelty:  0.12227762
p_int:  0.999996191
p_ni:  0.000003801
p_wrong:  9e-9
Data Source:  BioPlex
ALG14
Tbio
Family:  Enzyme
Novelty:  0.09271278
p_int:  0.999959376
p_ni:  0.000036202
p_wrong:  0.000004422
Data Source:  BioPlex
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.999828325
p_ni:  0.00013642
p_wrong:  0.000035255
Data Source:  BioPlex
CD9
Tbio
Novelty:  0.00095308
p_int:  0.99959999
p_ni:  0.000029403
p_wrong:  0.000370607
Score:  0.269
Data Source:  BioPlex,STRINGDB
EXTL2
Tbio
Family:  Enzyme
Novelty:  0.05051027
p_int:  0.998513293
p_ni:  0.001402554
p_wrong:  0.000084153
Data Source:  BioPlex
MTCH2
Tbio
Novelty:  0.01794294
p_int:  0.996381292
p_ni:  0.003618708
Data Source:  BioPlex
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.992960895
p_ni:  0.004465329
p_wrong:  0.002573776
Data Source:  BioPlex
TMEM186
Tdark
Novelty:  0.59951294
p_int:  0.987449247
p_ni:  0.009491701
p_wrong:  0.003059053
Data Source:  BioPlex
ULBP3
Tbio
Novelty:  0.0320239
p_int:  0.986726141
p_ni:  0.013242947
p_wrong:  0.000030912
Data Source:  BioPlex
FAM241B
Tdark
Novelty:  0.70797589
p_int:  0.985038193
p_ni:  0.014944607
p_wrong:  0.0000172
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
70.1
myeloid white cell count
1
1
1
68.2
leukocyte count
1
1
1
67.2
neutrophil count
1
1
1
67.1
glomerular filtration rate
3
1
3
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
70.1
myeloid white cell count
1
68.2
leukocyte count
1
67.2
neutrophil count
1
67.1
glomerular filtration rate
3
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 1
VGNC:10918
469191
Macaque
tetraspanin 1
707431
Mouse
MGI:1914055
66805
Rat
RGD:1303308
298436
Dog
tetraspanin 1
VGNC:47910
100856322
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 1
Macaque
tetraspanin 1
Mouse
Rat
Dog
tetraspanin 1
Publication Statistics
PubMed Score 65.24
PubMed score by year
PubTator Score 30.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title