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Tbio
TSNAX
Translin-associated protein X

Protein Summary
Description
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366639
  • ENSP00000355599
  • ENSG00000116918

Symbol
  • TRAX
  • C3PO
  • TRAX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.96
histone modification site profile
0.85
molecular function
0.84
virus perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.07   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.07   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
KIF2A
Tbio
Novelty:  0.01463006
p_int:  1
Score:  0.612
Data Source:  BioPlex,STRINGDB
CEP128
Tbio
Novelty:  0.15843064
p_int:  0.999999975
p_ni:  1.7e-8
p_wrong:  7e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
SOGA1
Tbio
Novelty:  0.08349978
p_int:  0.999999106
p_ni:  3.89e-7
p_wrong:  5.05e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
TSN
Tbio
Novelty:  0.00510474
p_int:  0.999998986
p_ni:  0.000001014
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  0.999997581
p_ni:  0.000002419
Score:  0.248
Data Source:  BioPlex,STRINGDB
MCM3
Tbio
Novelty:  0.00593382
p_int:  0.999963069
p_ni:  0.000036931
Score:  0.183
Data Source:  BioPlex,STRINGDB
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999746648
p_ni:  0.000253352
Score:  0.237
Data Source:  BioPlex,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999700236
p_ni:  0.000299752
p_wrong:  1.2e-8
Data Source:  BioPlex
GOLGA3
Tbio
Novelty:  0.03018438
p_int:  0.99928223
p_ni:  0.00071777
Score:  0.811
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.997630845
p_ni:  0.002369155
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
Small interfering RNA (siRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
Small interfering RNA (siRNA) biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
55.2
periodontal measurement
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
55.2
periodontal measurement
1
26.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translin associated factor X
VGNC:10919
457819
Macaque
translin associated factor X
713347
Mouse
MGI:1855672
53424
Rat
RGD:621574
64028
Dog
translin associated factor X
479203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translin associated factor X
Macaque
translin associated factor X
Mouse
Rat
Dog
translin associated factor X
Publication Statistics
PubMed Score 107.07
PubMed score by year
PubTator Score 44.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title