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Tbio
TSKS
Testis-specific serine kinase substrate

Protein Summary
Description
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development. This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246801
  • ENSP00000246801
  • ENSG00000126467

Symbol
  • STK22S1
  • TSKS1
  • TSKS1
  • TSSKS
  • STK22S1
  • PPP1R161
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
cell type or tissue
0.59
gene perturbation
0.57
cellular component
0.55
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
PGGT1B
Tchem
Family:  Enzyme
Novelty:  0.08041103
p_int:  0.999998174
p_ni:  0.000001821
p_wrong:  5e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
CAVIN1
Tbio
Family:  Enzyme
Novelty:  0.00780634
p_int:  0.999993839
p_ni:  0.000006161
Score:  0.239
Data Source:  BioPlex,STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
p_int:  0.999976559
p_ni:  0.000023438
p_wrong:  2e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999865991
p_ni:  0.000134009
p_wrong:  1e-9
Data Source:  BioPlex
BLOC1S2
Tbio
Novelty:  0.02346362
p_int:  0.999531597
p_ni:  0.000468219
p_wrong:  1.84e-7
Score:  0.524
Data Source:  BioPlex,STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.999449203
p_ni:  0.000550797
Data Source:  BioPlex
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999052253
p_ni:  0.000947747
Score:  0.2
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.999012257
p_ni:  0.000987743
Data Source:  BioPlex
CCDC85B
Tdark
Novelty:  0.02034018
p_int:  0.998888979
p_ni:  0.001099219
p_wrong:  0.000011802
Data Source:  BioPlex
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.998555473
p_ni:  0.001444484
p_wrong:  4.3e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
4
4
95.5
serum albumin measurement
1
4
4
92.1
urate measurement
2
2
4
71.8
autoimmune thyroid disease
1
1
0
1.1
47.7
1
1
0
1.1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
95.5
serum albumin measurement
4
92.1
urate measurement
4
71.8
autoimmune thyroid disease
0
1.1
47.7
0
1.1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
testis specific serine kinase substrate
VGNC:7493
748276
Macaque
testis specific serine kinase substrate
719028
Mouse
MGI:1347560
22116
Rat
RGD:727784
292890
Dog
testis specific serine kinase substrate
VGNC:47906
611897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
testis specific serine kinase substrate
Macaque
testis specific serine kinase substrate
Mouse
Rat
Dog
testis specific serine kinase substrate
Publication Statistics
PubMed Score 11.98
PubMed score by year
PubTator Score 3.40
PubTator score by year
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Related Publications
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PMID
Year
Title