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Tbio
TSHZ2
Teashirt homolog 2

Protein Summary
Description
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329613
  • ENSP00000333114
  • ENSG00000182463
  • ENST00000371497
  • ENSP00000360552
  • ENST00000603338
  • ENSP00000475114

Symbol
  • C20orf17
  • TSH2
  • ZNF218
  • TSH2
  • ZABC2
  • ZNF218
  • OVC10-2
  • C20orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
transcription factor perturbation
0.8
microRNA
0.78
transcription factor
0.77
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.11   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.11   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0