Protein Summary
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity). The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- ENST00000342443
- ENSP00000340113
- ENSG00000165409
- ENST00000554435
- ENSP00000450549
- LGR3
- LGR3
- CHNG1
- hTSHR-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.98 | ||
protein domain | 0.85 | ||
disease | 0.8 | ||
disease perturbation | 0.79 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1493.15 (req: < 5)
Gene RIFs: 234 (req: <= 3)
Antibodies: 1081 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1493.15 (req: >= 5)
Gene RIFs: 234 (req: > 3)
Antibodies: 1081 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (6)
Protein-Protein Interactions (221)
LAMA3
Novelty: 0.00733792
p_int: 0.987295952
p_ni: 0.012676485
p_wrong: 0.000027563
Score: 0.247
Data Source: BioPlex,STRINGDB
POTEF
Novelty: 0.00191599
p_int: 0.956270812
p_ni: 0.043729188
Score: 0.178
Data Source: BioPlex,STRINGDB
ITPA
Family: Enzyme
Novelty: 0.00235169
p_int: 0.951607631
p_ni: 0.003046031
p_wrong: 0.045346338
Score: 0.19
Data Source: BioPlex,STRINGDB
MOCOS
Family: Enzyme
Novelty: 0.05022905
p_int: 0.946301273
p_ni: 0.053695012
p_wrong: 0.000003715
Score: 0.173
Data Source: BioPlex,STRINGDB
BORA
Novelty: 0.0374925
p_int: 0.909799974
p_ni: 0.090061699
p_wrong: 0.000138328
Score: 0.189
Data Source: BioPlex,STRINGDB
PC
Family: Enzyme
Novelty: 0.00271694
p_int: 0.878394362
p_ni: 0.121605638
Score: 0.525
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (7)
KEGG (5)
PathwayCommons (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Hormone ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Hormone ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (4)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.4 | 91.7 | |||||
neutrophil count | 2 | 2 | 2 | 79.8 | |||||
myeloid white cell count | 1 | 1 | 1 | 69.8 | |||||
leukocyte count | 1 | 1 | 1 | 64 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 59.9 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 91.7 | |||||
neutrophil count | 2 | 79.8 | |||||
myeloid white cell count | 1 | 69.8 | |||||
leukocyte count | 1 | 64 | |||||
high density lipoprotein cholesterol measurement | 2 | 59.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thyroid stimulating hormone receptor | VGNC:3294 | 453077 | |||||
Macaque | thyroid stimulating hormone receptor | 574251 | ||||||
Mouse | MGI:98849 | 22095 | ||||||
Rat | RGD:3911 | 25360 | ||||||
Dog | thyroid stimulating hormone receptor | VGNC:47902 | 403968 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thyroid stimulating hormone receptor | |||||
Macaque | thyroid stimulating hormone receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | thyroid stimulating hormone receptor | |||||
Publication Statistics
PubMed Score 1493.15
PubMed score by year
PubTator Score 2607.72
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (340)
GeneRif Annotations (234)
Items per page:
0 of 0
PMID | Year | Title |
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