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Tbio
TSG101
Tumor susceptibility gene 101 protein

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251968
  • ENSP00000251968
  • ENSG00000074319

Symbol
  • TSG10
  • VPS23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
biological process
0.94
cellular component
0.91
histone modification site profile
0.89
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.05   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.05   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (221)
UBAP1
Tbio
Novelty:  0.02276845
p_int:  0.999798431
p_ni:  0.000201569
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
VPS37D
Tdark
Novelty:  1.44882563
p_int:  0.999327042
p_ni:  0.000672958
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.986818458
p_ni:  0.013181542
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS37B
Tbio
Novelty:  0.22081527
Score:  0.999
Data Source:  Reactome,STRINGDB
HGS
Tbio
Family:  Enzyme
Novelty:  0.00665044
Score:  0.998
Data Source:  Reactome,STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.997
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.997
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.996
Data Source:  STRINGDB
MVB12A
Tbio
Novelty:  0.09794
Score:  0.996
Data Source:  Reactome,STRINGDB
VPS36
Tbio
Novelty:  0.03382542
Score:  0.995
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (53)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
3
4
92.2
serum amyloid A protein measurement
1
1
1
74.5
total cholesterol measurement
2
2
5
66.6
body height
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
92.2
serum amyloid A protein measurement
1
74.5
total cholesterol measurement
5
66.6
body height
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor susceptibility 101
VGNC:949
451065
Macaque
tumor susceptibility 101
693787
Mouse
MGI:106581
22088
Rat
RGD:3909
292925
Dog
tumor susceptibility 101
VGNC:47898
485406
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor susceptibility 101
Macaque
tumor susceptibility 101
Mouse
Rat
Dog
tumor susceptibility 101
Publication Statistics
PubMed Score 495.05
PubMed score by year
PubTator Score 231.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title