Tbio TSFM Elongation factor Ts, mitochondrial

Protein Summary

Description

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• P43897
• B4E391
• F5H2T7
• Q561V7
• Q8TBC2
• Q9UQK0
• EF-Ts

Gene Name

• TSFM

Ensembl ID

• ENST00000323833
• ENSP00000313877
• ENSG00000123297
• ENST00000454289
• ENSP00000388330
• ENST00000540550
• ENSP00000440987
• ENST00000543727
• ENSP00000439342

Symbol

• EFTS
• EFTSMT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor binding site profile	0.8
transcription factor perturbation	0.74
protein domain	0.73
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Elongation Factor Ts, Mitochondrial

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Elongation Factor Ts, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Elongation Factor Ts, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.3   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.3   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0