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Tbio
TSEN54
tRNA-splicing endonuclease subunit Sen54

Protein Summary
Description
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also imp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333213
  • ENSP00000327487
  • ENSG00000182173

Symbol
  • SEN54
  • PCH4
  • PCH5
  • PCH2A
  • sen54
  • SEN54L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.84
kinase perturbation
0.76
transcription factor
0.75
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.999957781
p_ni:  0.000042219
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSEN15
Tbio
Family:  Enzyme
Novelty:  0.17606559
p_int:  0.999014776
p_ni:  0.000985224
Score:  0.998
Data Source:  BioPlex,STRINGDB
AMMECR1
Tbio
Novelty:  0.12679247
p_int:  0.800292741
p_ni:  0.199707259
Score:  0.519
Data Source:  BioPlex,STRINGDB
TSEN34
Tdark
Family:  Enzyme
Novelty:  0.06726323
Score:  0.998
Data Source:  STRINGDB
CLP1
Tbio
Family:  Enzyme
Novelty:  0.04643806
Score:  0.974
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.9
Data Source:  STRINGDB
CPSF4
Tbio
Novelty:  0.00206207
Score:  0.9
Data Source:  STRINGDB
CSTF2
Tbio
Novelty:  0.01389909
Score:  0.9
Data Source:  STRINGDB
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
Score:  0.87
Data Source:  STRINGDB
VRK1
Tbio
Family:  Kinase
Novelty:  0.00761136
Score:  0.831
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
2
1
1.2
70.4
sleep duration
1
2
2
54.2
high density lipoprotein cholesterol measurement
1
2
2
54.2
platelet count
1
1
1
42.3
heel bone mineral density
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
1.2
70.4
sleep duration
2
54.2
high density lipoprotein cholesterol measurement
2
54.2
platelet count
1
42.3
heel bone mineral density
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA splicing endonuclease subunit 54
VGNC:9743
737516
Macaque
tRNA splicing endonuclease subunit 54
702604
Mouse
MGI:1923515
76265
Rat
RGD:1597379
690308
Dog
tRNA splicing endonuclease subunit 54
VGNC:47897
483315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA splicing endonuclease subunit 54
Macaque
tRNA splicing endonuclease subunit 54
Mouse
Rat
Dog
tRNA splicing endonuclease subunit 54
Publication Statistics
PubMed Score 36.01
PubMed score by year
PubTator Score 33.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title