Tdark TSEN34 tRNA-splicing endonuclease subunit Sen34

Protein Summary

Description

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9BSV6
• A6NNB1
• B0V3J1
• Q9BVT1
• Q9H6H5

Gene Name

• TSEN34

Ensembl ID

• ENST00000302937
• ENSP00000305524
• ENSG00000170892
• ENST00000396383
• ENSP00000379667
• ENST00000396388
• ENSP00000379671
• ENST00000611560
• ENSP00000480422
• ENSG00000274796
• ENST00000611798
• ENSP00000480899
• ENSG00000278605
• ENST00000612236
• ENSP00000480503
• ENSG00000274129
• ENST00000612393
• ENSP00000478622
• ENSG00000278622
• ENST00000613310
• ENSP00000477766
• ENSG00000274078
• ENST00000613712
• ENSP00000484865
• ENSG00000273896
• ENST00000613888
• ENSP00000481068
• ENSG00000278712
• ENST00000614948
• ENSP00000478156
• ENST00000614984
• ENSP00000483266
• ENST00000615000
• ENSP00000479654
• ENST00000615079
• ENSP00000484694
• ENST00000615900
• ENSP00000484964
• ENST00000615975
• ENSP00000484225
• ENST00000616063
• ENSP00000480964
• ENST00000616209
• ENSP00000481374
• ENSG00000274672
• ENST00000617149
• ENSP00000481639
• ENST00000617902
• ENSP00000484465
• ENSG00000275165
• ENST00000618135
• ENSP00000479576
• ENST00000619994
• ENSP00000482084
• ENST00000622524
• ENSP00000483436
• ENST00000622538
• ENSP00000482527

Symbol

• LENG5
• SEN34
• LENG5
• PCH2C
• SEN34
• SEN34L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
disease perturbation	0.97
kinase perturbation	0.95
histone modification site profile	0.86
transcription factor binding site profile	0.81

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Trna-splicing Endonuclease Subunit Sen34

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Trna-splicing Endonuclease Subunit Sen34

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Trna-splicing Endonuclease Subunit Sen34

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0