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Tbio
TSEN2
tRNA-splicing endonuclease subunit Sen2

Protein Summary
Description
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284995
  • ENSP00000284995
  • ENSG00000154743
  • ENST00000402228
  • ENSP00000385976
  • ENST00000415684
  • ENSP00000416510
  • ENST00000444864
  • ENSP00000407974
  • ENST00000454502
  • ENSP00000392029

Symbol
  • SEN2
  • SEN2
  • PCH2B
  • SEN2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
transcription factor binding site profile
0.77
small molecule perturbation
0.68
cellular component
0.67
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.25   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.25   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
GREB1L
Tdark
Novelty:  0.06421593
p_int:  0.999999832
p_ni:  1.62e-7
p_wrong:  6e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
TSEN15
Tbio
Family:  Enzyme
Novelty:  0.17606559
p_int:  0.9999997
p_ni:  3e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TMED8
Tdark
Novelty:  1.41977071
p_int:  0.999959723
p_ni:  0.00004015
p_wrong:  1.27e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
TSEN54
Tbio
Family:  Enzyme
Novelty:  0.03157812
p_int:  0.999957781
p_ni:  0.000042219
Score:  0.999
Data Source:  BioPlex,STRINGDB
CLP1
Tbio
Family:  Enzyme
Novelty:  0.04643806
p_int:  0.999704569
p_ni:  0.000295431
Score:  0.99
Data Source:  BioPlex,STRINGDB
TSEN34
Tdark
Family:  Enzyme
Novelty:  0.06726323
p_int:  0.999608957
p_ni:  0.000391043
Score:  0.999
Data Source:  BioPlex,STRINGDB
SFSWAP
Tdark
Novelty:  0.2236256
p_int:  0.962510221
p_ni:  0.037474885
p_wrong:  0.000014894
Score:  0.187
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.895065471
p_ni:  0.104934529
Data Source:  BioPlex
ZNRF1
Tbio
Family:  Enzyme
Novelty:  0.15739853
p_int:  0.81716544
p_ni:  0.182834558
p_wrong:  2e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
CIB2
Tbio
Novelty:  0.03578691
p_int:  0.805891023
p_ni:  0.194108977
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
31
32
98.2
BMI-adjusted waist-hip ratio
6
31
38
98.1
hip circumference
1
18
18
97.1
BMI-adjusted hip circumference
2
17
19
96.1
BMI-adjusted waist circumference
1
14
14
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
32
98.2
BMI-adjusted waist-hip ratio
38
98.1
hip circumference
18
97.1
BMI-adjusted hip circumference
19
96.1
BMI-adjusted waist circumference
14
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2141599
381802
Dog
tRNA splicing endonuclease subunit 2
484651
Horse
tRNA splicing endonuclease subunit 2
100051185
Cow
tRNA splicing endonuclease subunit 2
515511
Pig
tRNA splicing endonuclease subunit 2
100525362
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
tRNA splicing endonuclease subunit 2
Horse
tRNA splicing endonuclease subunit 2
Cow
tRNA splicing endonuclease subunit 2
Pig
tRNA splicing endonuclease subunit 2
Publication Statistics
PubMed Score 24.25
PubMed score by year
PubTator Score 2.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title