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Tbio
TSC22D3
TSC22 domain family protein 3

Protein Summary
Description
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315660
  • ENSP00000314655
  • ENSG00000157514
  • ENST00000372383
  • ENSP00000361458
  • ENST00000372384
  • ENSP00000361459
  • ENST00000372397
  • ENSP00000361474
  • ENST00000506081
  • ENSP00000427427

Symbol
  • DSIPI
  • GILZ
  • DIP
  • GILZ
  • DSIPI
  • TSC-22R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.92
PubMedID
0.91
gene perturbation
0.84
histone modification site profile
0.81
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.87   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.87   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0