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Tbio
TSC22D1
TSC22 domain family protein 1

Protein Summary
Description
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261489
  • ENSP00000261489
  • ENSG00000102804
  • ENST00000458659
  • ENSP00000397435
  • ENST00000501704
  • ENSP00000437414

Symbol
  • KIAA1994
  • TGFB1I4
  • TSC22
  • Ptg-2
  • TSC22
  • TGFB1I4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.98
kinase perturbation
0.91
PubMedID
0.91
transcription factor
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.999999998
p_ni:  2e-9
Score:  0.502
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999999997
p_ni:  3e-9
Score:  0.807
Data Source:  BioPlex,STRINGDB
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
p_int:  0.999991659
p_ni:  0.00000834
p_wrong:  1e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.999193439
p_ni:  0.000806561
p_wrong:  1e-9
Score:  0.217
Data Source:  BioPlex,STRINGDB
SYNJ2BP
Tbio
Novelty:  0.02520087
p_int:  0.995911486
p_ni:  0.002979861
p_wrong:  0.001108652
Data Source:  BioPlex
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.961239392
p_ni:  0.034391312
p_wrong:  0.004369295
Data Source:  BioPlex
LDLRAD4
Tbio
Novelty:  0.04881486
Score:  0.836
Data Source:  STRINGDB
SART1
Tbio
Novelty:  0.00835627
Score:  0.642
Data Source:  STRINGDB
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
Score:  0.627
Data Source:  STRINGDB
ATP6V1A
Tbio
Family:  Enzyme
Novelty:  0.00921474
Score:  0.563
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109127
21807
Rat
RGD:3850
498545
Dog
TSC22 domain family member 1
VGNC:47892
476927
Horse
TSC22 domain family member 1 [Source:HGNC Symbol;Acc:HGNC:16826]
Pig
TSC22 domain family member 1
100155900
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TSC22 domain family member 1
Horse
TSC22 domain family member 1 [Source:HGNC Symbol;Acc:HGNC:16826]
Pig
TSC22 domain family member 1
Publication Statistics
PubMed Score 61.11
PubMed score by year
PubTator Score 43.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title