Protein Summary
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, ...more
- ENST00000298552
- ENSP00000298552
- ENSG00000165699
- ENST00000440111
- ENSP00000394524
- ENST00000545250
- ENSP00000444017
- ENST00000643072
- ENSP00000496691
- ENST00000643875
- ENSP00000495158
- ENST00000646625
- ENSP00000496263
- KIAA0243
- TSC
- LAM
- TSC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.97 | ||
disease perturbation | 0.93 | ||
hub protein | 0.92 | ||
histone modification site profile | 0.85 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 260.41 (req: < 5)
Gene RIFs: 156 (req: <= 3)
Antibodies: 1764 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 260.41 (req: >= 5)
Gene RIFs: 156 (req: > 3)
Antibodies: 1764 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 46
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (163)
AKTIP
Novelty: 0.00315951
p_int: 0.999867388
p_ni: 0.000132588
p_wrong: 2.4e-8
Score: 0.336
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (52)
Reactome (16)
KEGG (13)
PathwayCommons (5)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Energy dependent regulation of mTOR by LKB1-AMPK | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Energy dependent regulation of mTOR by LKB1-AMPK | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (61)
Functions (6)
Components (15)
Processes (40)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 9 | 13 | 98.4 | |||||
mean platelet volume | 4 | 4 | 6 | 98.4 | |||||
platelet count | 3 | 4 | 5 | 98.1 | |||||
eosinophil percentage of leukocytes | 2 | 7 | 10 | 97.4 | |||||
red blood cell distribution width | 3 | 4 | 6 | 97.2 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 13 | 98.4 | |||||
mean platelet volume | 6 | 98.4 | |||||
platelet count | 5 | 98.1 | |||||
eosinophil percentage of leukocytes | 10 | 97.4 | |||||
red blood cell distribution width | 6 | 97.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | TSC complex subunit 1 | VGNC:48987 | 464818 | |||||
Macaque | TSC complex subunit 1 | 714645 | ||||||
Mouse | MGI:1929183 | 64930 | ||||||
Rat | RGD:620124 | 60445 | ||||||
Dog | TSC complex subunit 1 | VGNC:47890 | 480688 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | TSC complex subunit 1 | |||||
Macaque | TSC complex subunit 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | TSC complex subunit 1 | |||||
Publication Statistics
PubMed Score 260.41
PubMed score by year
PubTator Score 929.17
PubTator score by year
Related Publications
Text Mined References (202)
GeneRif Annotations (156)
Items per page:
0 of 0
PMID | Year | Title |
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