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Tchem
TRPV4
Transient receptor potential cation channel subfamily V member 4

Protein Summary
Description
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecano ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261740
  • ENSP00000261740
  • ENSG00000111199
  • ENST00000418703
  • ENSP00000406191
  • ENST00000536838
  • ENSP00000444336
  • ENST00000537083
  • ENSP00000442738
  • ENST00000541794
  • ENSP00000442167
  • ENST00000544971
  • ENSP00000443611

Symbol
  • VRL2
  • VROAC
  • SMAL
  • VRL2
  • BCYM3
  • CMT2C
  • SPSMA
  • TRP12
  • VROAC
  • HMSN2C
  • OTRPC4
  • SSQTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.91
cellular component
0.91
protein domain
0.85
kinase
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.95   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1106.95   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 444
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (127)
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.92
Data Source:  STRINGDB
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
Score:  0.905
Data Source:  STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.873
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.867
Data Source:  STRINGDB
PACSIN3
Tbio
Family:  Enzyme
Novelty:  0.11715903
Score:  0.851
Data Source:  STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.825
Data Source:  STRINGDB
TRPC6
Tchem
Family:  IC
Novelty:  0.00118598
Score:  0.822
Data Source:  STRINGDB
PRKCE
Tchem
Family:  Kinase
Novelty:  0.00890161
Score:  0.821
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.802
Data Source:  STRINGDB
PRKCD
Tclin
Family:  Kinase
Novelty:  0.0009758
Score:  0.801
Data Source:  STRINGDB
Pathways (7)
Ion channel transport (R-HSA-983712)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (77)
Find Similar Targets
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
38.2
hemoglobin measurement
1
1
1
36.9
platelet count
1
1
1
35
glomerular filtration rate
1
1
1
29
neutrophil count
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
38.2
hemoglobin measurement
1
36.9
platelet count
1
35
glomerular filtration rate
1
29
neutrophil count
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 4
VGNC:8587
452225
Macaque
transient receptor potential cation channel subfamily V member 4
709605
Mouse
MGI:1926945
63873
Rat
RGD:69337
66026
Horse
transient receptor potential cation channel subfamily V member 4
VGNC:24567
100066552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 4
Macaque
transient receptor potential cation channel subfamily V member 4
Mouse
Rat
Horse
transient receptor potential cation channel subfamily V member 4
Publication Statistics
PubMed Score 1106.95
PubMed score by year
PubTator Score 417.34
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title