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Tchem
TRPV4
Transient receptor potential cation channel subfamily V member 4

Protein Summary
Description
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecano ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261740
  • ENSP00000261740
  • ENSG00000111199
  • ENST00000418703
  • ENSP00000406191
  • ENST00000536838
  • ENSP00000444336
  • ENST00000537083
  • ENSP00000442738
  • ENST00000541794
  • ENSP00000442167
  • ENST00000544971
  • ENSP00000443611

Symbol
  • VRL2
  • VROAC
  • SMAL
  • VRL2
  • BCYM3
  • CMT2C
  • SPSMA
  • TRP12
  • VROAC
  • HMSN2C
  • OTRPC4
  • SSQTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.91
cellular component
0.91
protein domain
0.85
kinase
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1259.12   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1259.12   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 475
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0