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Tchem
TRPV2
Transient receptor potential cation channel subfamily V member 2

Protein Summary
Description
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338560
  • ENSP00000342222
  • ENSG00000187688

Symbol
  • VRL
  • VRL
  • VRL1
  • VRL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cellular component
0.69
tissue
0.65
biological process
0.64
ligand (chemical)
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.51   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.51   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (64)
TRPM7
Tchem
Family:  IC
Novelty:  0.00265096
Score:  0.954
Data Source:  STRINGDB
TRPM2
Tchem
Family:  IC
Novelty:  0.0076305
Score:  0.928
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.903
Data Source:  STRINGDB
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
Score:  0.891
Data Source:  STRINGDB
TRPA1
Tclin
Family:  IC
Novelty:  0.00093648
Score:  0.889
Data Source:  STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.788
Data Source:  STRINGDB
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
Score:  0.781
Data Source:  STRINGDB
TRPC6
Tchem
Family:  IC
Novelty:  0.00118598
Score:  0.774
Data Source:  STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.773
Data Source:  STRINGDB
TRPM3
Tchem
Family:  IC
Novelty:  0.00647452
Score:  0.761
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
2
2
63
smoking status measurement
2
1
2
40.7
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
63
smoking status measurement
2
40.7
self reported educational attainment
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 2
VGNC:9742
455014
Macaque
transient receptor potential cation channel subfamily V member 2
695986
Mouse
MGI:1341836
22368
Rat
RGD:3965
29465
Dog
transient receptor potential cation channel subfamily V member 2
VGNC:47883
489522
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 2
Macaque
transient receptor potential cation channel subfamily V member 2
Mouse
Rat
Dog
transient receptor potential cation channel subfamily V member 2
Publication Statistics
PubMed Score 241.51
PubMed score by year
PubTator Score 109.09
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title