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Tclin
TRPM8
Transient receptor potential cation channel subfamily M member 8

Protein Summary
Description
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outwar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324695
  • ENSP00000323926
  • ENSG00000144481
  • ENST00000409625
  • ENSP00000386771

Symbol
  • LTRPC6
  • TRPP8
  • TRPP8
  • LTRPC6
  • trp-p8
  • LTrpC-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.89
cellular component
0.81
molecular function
0.76
biological term
0.58
cell type or tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 873.12   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 873.12   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 517
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1