Transient receptor potential cation channel subfamily M member 8
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outwar ...more
PANTHER Classes Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily M Member 8 Protein / Receptor / Transient Receptor Potential Cation Channel Subfamily M Member 8
Description of the protein which includes the UniProt Function and the NCBI Gene Summary.
Uniprot linked accession values, symbols or commonly used abbreviations associated with this particular target.
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Jensen Lab generated fractional counting score for the prevalence of this gene in Pubmed articles.
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Ligands associated with a target, listed in ChEMBL, with activity over a cutoff relative to the targetclass.